Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912611209> ?p ?o ?g. }
- W2912611209 endingPage "510" @default.
- W2912611209 startingPage "498" @default.
- W2912611209 abstract "Abstract Drug repositioning has become a prevailing tactic as this strategy is efficient, economical and low risk for drug discovery. Meanwhile, recent studies have confirmed that small-molecule drugs can modulate the expression of disease-related miRNAs, which indicates that miRNAs are promising therapeutic targets for complex diseases. In this study, we put forward and verified the hypothesis that drugs with similar miRNA profiles may share similar therapeutic properties. Furthermore, a comprehensive drug–drug interaction network was constructed based on curated drug-miRNA associations. Through random network comparison, topological structure analysis and network module extraction, we found that the closely linked drugs in the network tend to treat the same diseases. Additionally, the curated drug–disease relationships (from the CTD) and random walk with restarts algorithm were utilized on the drug–drug interaction network to identify the potential drugs for a given disease. Both internal validation (leave-one-out cross-validation) and external validation (independent drug–disease data set from the ChEMBL) demonstrated the effectiveness of the proposed approach. Finally, by integrating drug-miRNA and miRNA-disease information, we also explain the modes of action of drugs in the view of miRNA regulation. In summary, our work could determine novel and credible drug indications and offer novel insights and valuable perspectives for drug repositioning." @default.
- W2912611209 created "2019-02-21" @default.
- W2912611209 creator A5012522085 @default.
- W2912611209 creator A5017247859 @default.
- W2912611209 creator A5017347072 @default.
- W2912611209 creator A5040745136 @default.
- W2912611209 creator A5047395203 @default.
- W2912611209 creator A5050522867 @default.
- W2912611209 creator A5051048714 @default.
- W2912611209 date "2019-02-11" @default.
- W2912611209 modified "2023-09-25" @default.
- W2912611209 title "In silico drug repositioning based on drug-miRNA associations" @default.
- W2912611209 cites W1889514258 @default.
- W2912611209 cites W1963906441 @default.
- W2912611209 cites W1975441976 @default.
- W2912611209 cites W1976024273 @default.
- W2912611209 cites W1983083889 @default.
- W2912611209 cites W1984084871 @default.
- W2912611209 cites W1985904021 @default.
- W2912611209 cites W1986306953 @default.
- W2912611209 cites W1991394667 @default.
- W2912611209 cites W1994658365 @default.
- W2912611209 cites W1995051807 @default.
- W2912611209 cites W1997541686 @default.
- W2912611209 cites W2000267962 @default.
- W2912611209 cites W2000417339 @default.
- W2912611209 cites W2008842579 @default.
- W2912611209 cites W2024311391 @default.
- W2912611209 cites W2029124536 @default.
- W2912611209 cites W2029287872 @default.
- W2912611209 cites W2034044377 @default.
- W2912611209 cites W2043496866 @default.
- W2912611209 cites W2044967196 @default.
- W2912611209 cites W2048685154 @default.
- W2912611209 cites W2048853752 @default.
- W2912611209 cites W2061016350 @default.
- W2912611209 cites W2062941476 @default.
- W2912611209 cites W2064131445 @default.
- W2912611209 cites W2067915426 @default.
- W2912611209 cites W2071969529 @default.
- W2912611209 cites W2079761894 @default.
- W2912611209 cites W2083045667 @default.
- W2912611209 cites W2092942708 @default.
- W2912611209 cites W2094791588 @default.
- W2912611209 cites W2095225725 @default.
- W2912611209 cites W2096541451 @default.
- W2912611209 cites W2098880370 @default.
- W2912611209 cites W2106210472 @default.
- W2912611209 cites W2108508085 @default.
- W2912611209 cites W2109115947 @default.
- W2912611209 cites W2109120098 @default.
- W2912611209 cites W2110462918 @default.
- W2912611209 cites W2112243395 @default.
- W2912611209 cites W2115735198 @default.
- W2912611209 cites W2121175754 @default.
- W2912611209 cites W2121604817 @default.
- W2912611209 cites W2123699903 @default.
- W2912611209 cites W2125899548 @default.
- W2912611209 cites W2127553917 @default.
- W2912611209 cites W2128498298 @default.
- W2912611209 cites W2130018512 @default.
- W2912611209 cites W2134617070 @default.
- W2912611209 cites W2136850043 @default.
- W2912611209 cites W2144656637 @default.
- W2912611209 cites W2145864981 @default.
- W2912611209 cites W2150965189 @default.
- W2912611209 cites W2151357092 @default.
- W2912611209 cites W2153661117 @default.
- W2912611209 cites W2153838454 @default.
- W2912611209 cites W2154896031 @default.
- W2912611209 cites W2155157373 @default.
- W2912611209 cites W2158135353 @default.
- W2912611209 cites W2166209362 @default.
- W2912611209 cites W2172024938 @default.
- W2912611209 cites W2175694606 @default.
- W2912611209 cites W2233072063 @default.
- W2912611209 cites W2272984102 @default.
- W2912611209 cites W2318071077 @default.
- W2912611209 cites W2318932315 @default.
- W2912611209 cites W2345332223 @default.
- W2912611209 cites W2346950316 @default.
- W2912611209 cites W2347018789 @default.
- W2912611209 cites W2383467331 @default.
- W2912611209 cites W2406756364 @default.
- W2912611209 cites W2469884426 @default.
- W2912611209 cites W2493614923 @default.
- W2912611209 cites W2544570105 @default.
- W2912611209 cites W2619665910 @default.
- W2912611209 cites W2738568220 @default.
- W2912611209 cites W2741613334 @default.
- W2912611209 cites W2768768021 @default.
- W2912611209 cites W2789606268 @default.
- W2912611209 cites W2802535993 @default.
- W2912611209 cites W2805151159 @default.
- W2912611209 cites W2883033700 @default.
- W2912611209 cites W2892573831 @default.
- W2912611209 cites W2897276244 @default.
- W2912611209 cites W2915806464 @default.