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- W2912615328 abstract "Antibacterial drugs can become more efficient against bacteria on coordination with transition metals. In this context, the current study focused on the synthesis and characterization of antibiotic metal complexes and in vitro evaluation of their antibacterial efficacy. The complex 1, FeCl3(L1)2H2O (Penicillin G and Iron) and complex 2, Ni(NO3)2(L2)2H2O (Ciprofloxacin and nickel) were synthesized via refluxing reaction and characterized by FTIR, TG/DTA, DLS, Powder XRD, FESEM, and Elemental analysis. Both the complexes were found to be biologically active with enhanced efficacy. Activities were measured by the zone of inhibition, minimal inhibitory concentration and growth pattern of bacteria. Serratia sp. R1, Serratia sp. W1 and Staphylococcus sp.Y1 were found to be sensitive against both, the complex 1 and complex 2 while Bacillus sp. K1 showed minor activity. Antibiotic-metal complex showed enhanced activity. Hence, a combination of antibiotics with metal salts may be an efficient and better option and might prove to be an alternative treatment against the resistant bacteria." @default.
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- W2912615328 date "2019-05-01" @default.
- W2912615328 modified "2023-10-18" @default.
- W2912615328 title "Synthesis and characterization of antibiotic-metal complexes [FeCl3(L1)2H2O and Ni(NO3)2(L2)2H2O] and enhanced antibacterial activity" @default.
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- W2912615328 doi "https://doi.org/10.1016/j.enmm.2019.100209" @default.
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