FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912621576> ?p ?o ?g. }

• W2912621576 endingPage "10" @default.
• W2912621576 startingPage "1" @default.
• W2912621576 abstract "Chronic lead (Pb) exposure has been shown to reduce the expression of some synaptic proteins which are involved in vesicular trafficking and affect presynaptic neurotransmitter release. However, the precise mechanisms by Pb impairs neurotransmitter release are still not well defined. In the current study, we aimed to elucidate the changes of Huntingtin-associated protein 1 (HAP1) in Pb exposed rats and PC12 cells models and its molecular mechanism. Repressor element-1 silencing transcription (REST) modulates the expression of genes containing the repressor element 1 (RE-1) cis-regulatory DNA sequence. HAP1 promoter region contains a RE-1 binding motif. We also observed whether Pb exposure regulated the HAP1 transcription level through influencing the expression of REST. Mother rats were exposed to 0.5 and 2 g/L Pb acetate (PbAc) in drinking water from the first day of gestation until postnatal 21 days, then the offspring rats were continued to drink PbAc for 1 year, while the control groups received drinking water. PC12 cells were divided into 3 groups: 0 μM, 1 μM and 100 μM PbAc. The results revealed that Pb levels in blood and brain of Pb exposed groups were significantly higher than that of the control group. The ability of learning and memory in Pb exposed rats was decreased. Pb exposure reduced the expression of HAP1 and increased the REST expression. Silencing REST could reverse the decreasing of HAP1 in Pb exposed PC12 cells. Our findings raise a possibility that the decreasing of HAP1 expression by Pb exposure may affect neurotransmitter release and results in impairments in spatial learning and memory ability." @default.
• W2912621576 created "2019-02-21" @default.
• W2912621576 creator A5025254929 @default.
• W2912621576 creator A5047854309 @default.
• W2912621576 creator A5077503978 @default.
• W2912621576 creator A5090200628 @default.
• W2912621576 date "2019-05-01" @default.
• W2912621576 modified "2023-10-14" @default.
• W2912621576 title "Chronic lead exposure decreases the expression of Huntingtin-associated protein 1 (HAP1) through Repressor element-1 silencing transcription (REST)" @default.
• W2912621576 cites W1493861611 @default.
• W2912621576 cites W1509279614 @default.
• W2912621576 cites W1974683080 @default.
• W2912621576 cites W1978104052 @default.
• W2912621576 cites W1983815752 @default.
• W2912621576 cites W1985325299 @default.
• W2912621576 cites W1995017656 @default.
• W2912621576 cites W1996344202 @default.
• W2912621576 cites W2008202443 @default.
• W2912621576 cites W2043944525 @default.
• W2912621576 cites W2045181869 @default.
• W2912621576 cites W2045871851 @default.
• W2912621576 cites W2049498756 @default.
• W2912621576 cites W2054295934 @default.
• W2912621576 cites W2061358750 @default.
• W2912621576 cites W2065005507 @default.
• W2912621576 cites W2066791114 @default.
• W2912621576 cites W2081954750 @default.
• W2912621576 cites W2091004905 @default.
• W2912621576 cites W2091323369 @default.
• W2912621576 cites W2102226249 @default.
• W2912621576 cites W2112367847 @default.
• W2912621576 cites W2118667823 @default.
• W2912621576 cites W2120705392 @default.
• W2912621576 cites W2121845150 @default.
• W2912621576 cites W2123673927 @default.
• W2912621576 cites W2128958924 @default.
• W2912621576 cites W2142716581 @default.
• W2912621576 cites W2148543906 @default.
• W2912621576 cites W2155924717 @default.
• W2912621576 cites W2159269805 @default.
• W2912621576 cites W2164031898 @default.
• W2912621576 cites W2224911713 @default.
• W2912621576 cites W2440302549 @default.
• W2912621576 cites W2467357685 @default.
• W2912621576 cites W2505865713 @default.
• W2912621576 cites W2544440759 @default.
• W2912621576 cites W2575543841 @default.
• W2912621576 cites W2593031948 @default.
• W2912621576 cites W2616748789 @default.
• W2912621576 cites W2731305200 @default.
• W2912621576 cites W2743824659 @default.
• W2912621576 cites W2791429709 @default.
• W2912621576 cites W2793999561 @default.
• W2912621576 cites W2796688219 @default.
• W2912621576 cites W2805484591 @default.
• W2912621576 doi "https://doi.org/10.1016/j.toxlet.2019.02.003" @default.
• W2912621576 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30742882" @default.
• W2912621576 hasPublicationYear "2019" @default.
• W2912621576 type Work @default.
• W2912621576 sameAs 2912621576 @default.
• W2912621576 citedByCount "5" @default.
• W2912621576 countsByYear W29126215762021 @default.
• W2912621576 countsByYear W29126215762022 @default.
• W2912621576 countsByYear W29126215762023 @default.
• W2912621576 crossrefType "journal-article" @default.
• W2912621576 hasAuthorship W2912621576A5025254929 @default.
• W2912621576 hasAuthorship W2912621576A5047854309 @default.
• W2912621576 hasAuthorship W2912621576A5077503978 @default.
• W2912621576 hasAuthorship W2912621576A5090200628 @default.
• W2912621576 hasConcept C104317684 @default.
• W2912621576 hasConcept C119056186 @default.
• W2912621576 hasConcept C126322002 @default.
• W2912621576 hasConcept C134018914 @default.
• W2912621576 hasConcept C138885662 @default.
• W2912621576 hasConcept C143065580 @default.
• W2912621576 hasConcept C150194340 @default.
• W2912621576 hasConcept C158448853 @default.
• W2912621576 hasConcept C179926584 @default.
• W2912621576 hasConcept C185592680 @default.
• W2912621576 hasConcept C2776219046 @default.
• W2912621576 hasConcept C2781427258 @default.
• W2912621576 hasConcept C41895202 @default.
• W2912621576 hasConcept C529278444 @default.
• W2912621576 hasConcept C55493867 @default.
• W2912621576 hasConcept C71924100 @default.
• W2912621576 hasConcept C86339819 @default.
• W2912621576 hasConcept C86803240 @default.
• W2912621576 hasConcept C95444343 @default.
• W2912621576 hasConceptScore W2912621576C104317684 @default.
• W2912621576 hasConceptScore W2912621576C119056186 @default.
• W2912621576 hasConceptScore W2912621576C126322002 @default.
• W2912621576 hasConceptScore W2912621576C134018914 @default.
• W2912621576 hasConceptScore W2912621576C138885662 @default.
• W2912621576 hasConceptScore W2912621576C143065580 @default.
• W2912621576 hasConceptScore W2912621576C150194340 @default.
• W2912621576 hasConceptScore W2912621576C158448853 @default.
• W2912621576 hasConceptScore W2912621576C179926584 @default.
• W2912621576 hasConceptScore W2912621576C185592680 @default.

• next