FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912621657> ?p ?o ?g. }

• W2912621657 abstract "Resistance to radiotherapy results in relapse and treatment failure in locally advanced esophageal squamous cell carcinoma (ESCC). High mobility group box 1 (HMGB1) is reported to be associated with the radioresistance in bladder and breast cancer. However, the role of HMGB1 in the radiotherapy response in ESCC has not been fully elucidated. Here, we investigated the role of HMGB1 to radioresistance in ESCC clinical samples and cell lines. We found that HMGB1 expression was associated with tumor recurrence after postoperative radiotherapy in locally advanced ESCC patients. HMGB1 knockdown in ESCC cells resulted in increased radiosensitivity both in vitro and in vivo. Autophagy level was found depressed in HMGB1 inhibition cells and activation of autophagy brought back cell's radioresistance. Our results demonstrate that HMGB1 activate autophagy and consequently promote radioresistance. HMGB1 may be used as a predictor of poor response to radiotherapy in ESCC patients. Our finding also highlights the importance of the utility of HMGB1 in ESCC radiosensitization." @default.
• W2912621657 created "2019-02-21" @default.
• W2912621657 creator A5024897978 @default.
• W2912621657 creator A5025492532 @default.
• W2912621657 creator A5030449023 @default.
• W2912621657 creator A5054232796 @default.
• W2912621657 creator A5063165259 @default.
• W2912621657 creator A5064273061 @default.
• W2912621657 creator A5067237708 @default.
• W2912621657 creator A5074350121 @default.
• W2912621657 creator A5075116238 @default.
• W2912621657 creator A5079281360 @default.
• W2912621657 creator A5088637689 @default.
• W2912621657 date "2019-02-12" @default.
• W2912621657 modified "2023-10-08" @default.
• W2912621657 title "High mobility group box 1 promotes radioresistance in esophageal squamous cell carcinoma cell lines by modulating autophagy" @default.
• W2912621657 cites W186697411 @default.
• W2912621657 cites W1950728748 @default.
• W2912621657 cites W1971264344 @default.
• W2912621657 cites W2018653121 @default.
• W2912621657 cites W2035568982 @default.
• W2912621657 cites W2058188455 @default.
• W2912621657 cites W2094277584 @default.
• W2912621657 cites W2114242405 @default.
• W2912621657 cites W2133197713 @default.
• W2912621657 cites W2145248738 @default.
• W2912621657 cites W2148287035 @default.
• W2912621657 cites W2278657612 @default.
• W2912621657 cites W2340386540 @default.
• W2912621657 cites W2414157364 @default.
• W2912621657 cites W2416835356 @default.
• W2912621657 cites W2547086728 @default.
• W2912621657 cites W2593759473 @default.
• W2912621657 cites W2611289202 @default.
• W2912621657 cites W2739160334 @default.
• W2912621657 cites W2746317228 @default.
• W2912621657 cites W2752326209 @default.
• W2912621657 cites W2794847062 @default.
• W2912621657 cites W2795302722 @default.
• W2912621657 cites W4211048478 @default.
• W2912621657 cites W47992729 @default.
• W2912621657 doi "https://doi.org/10.1038/s41419-019-1355-1" @default.
• W2912621657 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6372718" @default.
• W2912621657 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30755598" @default.
• W2912621657 hasPublicationYear "2019" @default.
• W2912621657 type Work @default.
• W2912621657 sameAs 2912621657 @default.
• W2912621657 citedByCount "24" @default.
• W2912621657 countsByYear W29126216572019 @default.
• W2912621657 countsByYear W29126216572020 @default.
• W2912621657 countsByYear W29126216572021 @default.
• W2912621657 countsByYear W29126216572022 @default.
• W2912621657 countsByYear W29126216572023 @default.
• W2912621657 crossrefType "journal-article" @default.
• W2912621657 hasAuthorship W2912621657A5024897978 @default.
• W2912621657 hasAuthorship W2912621657A5025492532 @default.
• W2912621657 hasAuthorship W2912621657A5030449023 @default.
• W2912621657 hasAuthorship W2912621657A5054232796 @default.
• W2912621657 hasAuthorship W2912621657A5063165259 @default.
• W2912621657 hasAuthorship W2912621657A5064273061 @default.
• W2912621657 hasAuthorship W2912621657A5067237708 @default.
• W2912621657 hasAuthorship W2912621657A5074350121 @default.
• W2912621657 hasAuthorship W2912621657A5075116238 @default.
• W2912621657 hasAuthorship W2912621657A5079281360 @default.
• W2912621657 hasAuthorship W2912621657A5088637689 @default.
• W2912621657 hasBestOaLocation W29126216571 @default.
• W2912621657 hasConcept C126322002 @default.
• W2912621657 hasConcept C143998085 @default.
• W2912621657 hasConcept C1491633281 @default.
• W2912621657 hasConcept C173396325 @default.
• W2912621657 hasConcept C190283241 @default.
• W2912621657 hasConcept C203522944 @default.
• W2912621657 hasConcept C206684579 @default.
• W2912621657 hasConcept C2776914184 @default.
• W2912621657 hasConcept C2780545709 @default.
• W2912621657 hasConcept C502942594 @default.
• W2912621657 hasConcept C509974204 @default.
• W2912621657 hasConcept C54355233 @default.
• W2912621657 hasConcept C55493867 @default.
• W2912621657 hasConcept C58962609 @default.
• W2912621657 hasConcept C71924100 @default.
• W2912621657 hasConcept C81885089 @default.
• W2912621657 hasConcept C86803240 @default.
• W2912621657 hasConceptScore W2912621657C126322002 @default.
• W2912621657 hasConceptScore W2912621657C143998085 @default.
• W2912621657 hasConceptScore W2912621657C1491633281 @default.
• W2912621657 hasConceptScore W2912621657C173396325 @default.
• W2912621657 hasConceptScore W2912621657C190283241 @default.
• W2912621657 hasConceptScore W2912621657C203522944 @default.
• W2912621657 hasConceptScore W2912621657C206684579 @default.
• W2912621657 hasConceptScore W2912621657C2776914184 @default.
• W2912621657 hasConceptScore W2912621657C2780545709 @default.
• W2912621657 hasConceptScore W2912621657C502942594 @default.
• W2912621657 hasConceptScore W2912621657C509974204 @default.
• W2912621657 hasConceptScore W2912621657C54355233 @default.
• W2912621657 hasConceptScore W2912621657C55493867 @default.
• W2912621657 hasConceptScore W2912621657C58962609 @default.
• W2912621657 hasConceptScore W2912621657C71924100 @default.
• W2912621657 hasConceptScore W2912621657C81885089 @default.
• W2912621657 hasConceptScore W2912621657C86803240 @default.

• next