Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912621783> ?p ?o ?g. }
- W2912621783 endingPage "1492" @default.
- W2912621783 startingPage "1485" @default.
- W2912621783 abstract "Design of new multifunctional nanosystems to integrate diagnostic and therapeutic functions is a major area of interest in the field of nanobiotechnology and nanomedicine. In this study, application of a new magnetic multilayered nanobiohybrid system composed of magnetite nanoparticles, silica, and albumin as a theranostic agent was investigated. Once the clusters of magnetite nanoparticles were coated with a silica shell, bovine serum albumin was conjugated to the surface of activated amine-MS particles (BMS). Afterwards, a curcumin-loaded albumin shell was formed on BMS particles (CBBMS). The curcumin loading capacity and efficiency of the nanobiohybrid particles were 93 ± 6 (mg drug/g particles) and 24 ± 1.7 (wt%), respectively. A sustained release profile was observed for the curcumin in PBS which followed the first-order kinetic model. Cytotoxicity evaluation of CBBMS showed a striking reduced IC50 value (9.9 μM) in comparison to that of the free curcumin (16.2 μM), tested on SH-SY5Y cells using MTT assay. Finally, the in vitro relaxivity experiments indicated a high transverse relaxivity (r2) of 369.7 mM-1 s-1 for the superparamagnetic nanobiohybrid particles in magnetic resonance imaging (MRI) tests. The obtained results in drug delivery and MRI tests recommend the as-prepared multilayered nanobiohybrid particles as an efficient and suitable system for theranostic applications." @default.
- W2912621783 created "2019-02-21" @default.
- W2912621783 creator A5003253049 @default.
- W2912621783 creator A5019783103 @default.
- W2912621783 creator A5020582439 @default.
- W2912621783 creator A5046997588 @default.
- W2912621783 date "2019-06-01" @default.
- W2912621783 modified "2023-10-17" @default.
- W2912621783 title "Theranostic magnetite cluster@silica@albumin double-shell particles as suitable carriers for water-insoluble drugs and enhanced T2 MR imaging contrast agents" @default.
- W2912621783 cites W1927788755 @default.
- W2912621783 cites W1965538863 @default.
- W2912621783 cites W1992891617 @default.
- W2912621783 cites W1995561619 @default.
- W2912621783 cites W2020055240 @default.
- W2912621783 cites W2022948223 @default.
- W2912621783 cites W2036954929 @default.
- W2912621783 cites W2042322146 @default.
- W2912621783 cites W2044970615 @default.
- W2912621783 cites W2123118992 @default.
- W2912621783 cites W2124720032 @default.
- W2912621783 cites W2145828709 @default.
- W2912621783 cites W2146765462 @default.
- W2912621783 cites W2170082734 @default.
- W2912621783 cites W2307619826 @default.
- W2912621783 cites W2314138181 @default.
- W2912621783 cites W2328572470 @default.
- W2912621783 cites W2328743335 @default.
- W2912621783 cites W2344955738 @default.
- W2912621783 cites W2348101575 @default.
- W2912621783 cites W2401118467 @default.
- W2912621783 cites W2522229411 @default.
- W2912621783 cites W2547560835 @default.
- W2912621783 cites W2552731913 @default.
- W2912621783 cites W2553537041 @default.
- W2912621783 cites W2585791695 @default.
- W2912621783 cites W2589518486 @default.
- W2912621783 cites W2593470870 @default.
- W2912621783 cites W2593898886 @default.
- W2912621783 cites W2606961903 @default.
- W2912621783 cites W2608270023 @default.
- W2912621783 cites W2612075071 @default.
- W2912621783 cites W2626600817 @default.
- W2912621783 cites W2742693704 @default.
- W2912621783 cites W2769344080 @default.
- W2912621783 cites W2887226517 @default.
- W2912621783 doi "https://doi.org/10.1016/j.msec.2019.02.063" @default.
- W2912621783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30889683" @default.
- W2912621783 hasPublicationYear "2019" @default.
- W2912621783 type Work @default.
- W2912621783 sameAs 2912621783 @default.
- W2912621783 citedByCount "13" @default.
- W2912621783 countsByYear W29126217832019 @default.
- W2912621783 countsByYear W29126217832020 @default.
- W2912621783 countsByYear W29126217832021 @default.
- W2912621783 countsByYear W29126217832022 @default.
- W2912621783 countsByYear W29126217832023 @default.
- W2912621783 crossrefType "journal-article" @default.
- W2912621783 hasAuthorship W2912621783A5003253049 @default.
- W2912621783 hasAuthorship W2912621783A5019783103 @default.
- W2912621783 hasAuthorship W2912621783A5020582439 @default.
- W2912621783 hasAuthorship W2912621783A5046997588 @default.
- W2912621783 hasConcept C115260700 @default.
- W2912621783 hasConcept C121332964 @default.
- W2912621783 hasConcept C13245373 @default.
- W2912621783 hasConcept C13965031 @default.
- W2912621783 hasConcept C15083742 @default.
- W2912621783 hasConcept C155672457 @default.
- W2912621783 hasConcept C171250308 @default.
- W2912621783 hasConcept C185592680 @default.
- W2912621783 hasConcept C191897082 @default.
- W2912621783 hasConcept C192562407 @default.
- W2912621783 hasConcept C23792430 @default.
- W2912621783 hasConcept C26926545 @default.
- W2912621783 hasConcept C2777781897 @default.
- W2912621783 hasConcept C2778250585 @default.
- W2912621783 hasConcept C2778978742 @default.
- W2912621783 hasConcept C2779820397 @default.
- W2912621783 hasConcept C2910607562 @default.
- W2912621783 hasConcept C32546565 @default.
- W2912621783 hasConcept C43617362 @default.
- W2912621783 hasConcept C55493867 @default.
- W2912621783 hasConcept C62520636 @default.
- W2912621783 hasConcept C86807702 @default.
- W2912621783 hasConcept C87023908 @default.
- W2912621783 hasConceptScore W2912621783C115260700 @default.
- W2912621783 hasConceptScore W2912621783C121332964 @default.
- W2912621783 hasConceptScore W2912621783C13245373 @default.
- W2912621783 hasConceptScore W2912621783C13965031 @default.
- W2912621783 hasConceptScore W2912621783C15083742 @default.
- W2912621783 hasConceptScore W2912621783C155672457 @default.
- W2912621783 hasConceptScore W2912621783C171250308 @default.
- W2912621783 hasConceptScore W2912621783C185592680 @default.
- W2912621783 hasConceptScore W2912621783C191897082 @default.
- W2912621783 hasConceptScore W2912621783C192562407 @default.
- W2912621783 hasConceptScore W2912621783C23792430 @default.
- W2912621783 hasConceptScore W2912621783C26926545 @default.
- W2912621783 hasConceptScore W2912621783C2777781897 @default.
- W2912621783 hasConceptScore W2912621783C2778250585 @default.