FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912629617> ?p ?o ?g. }

• W2912629617 endingPage "110" @default.
• W2912629617 startingPage "98" @default.
• W2912629617 abstract "Myelin disruptions are frequently reported in human immunodeficiency virus (HIV)-infected individuals and can occur in the CNS very early in the disease process. Immature oligodendrocytes (OLs) are quite sensitive to toxic increases in [Ca2+ ]i caused by exposure to HIV-1 Tat (transactivator of transcription, a protein essential for HIV replication and gene expression), but sensitivity to Tat-induced [Ca2+ ]i is reduced in mature OLs. Tat exposure also increased the activity of Ca2+ /calmodulin-dependent kinase IIβ (CaMKIIβ), the major isoform of CaMKII expressed by OLs, in both immature and mature OLs. Since CaMKIIβ is reported to interact with glycogen synthase kinase 3β (GSK3β), and GSK3β activity is implicated in OL apoptosis as well as HIV neuropathology, we hypothesized that disparate effects of Tat on OL viability with maturity might be because of an altered balance of CaMKIIβ-GSK3β activities. Tat expression in vivo led to increased CaMKIIβ and GSK3β activity in multiple brain regions in transgenic mice. In vitro, immature murine OLs expressed higher levels of GSK3β, but much lower levels of CaMKIIβ, than did mature OLs. Exogenous Tat up-regulated GSK3β activity in immature, but not mature, OLs. Tat-induced death of immature OLs was rescued by the GSK3β inhibitors valproic acid or SB415286, supporting involvement of GSK3β signaling. Pharmacologically inhibiting CaMKIIβ increased GSK3β activity in Tat-treated OLs, and genetically knocking down CaMKIIβ promoted death in mature OL cultures treated with Tat. Together, these results suggest that the effects of Tat on OL viability are dependent on CaMKIIβ-GSK3β interactions, and that increasing CaMKIIβ activity is a potential approach for limiting OL/myelin injury with HIV infection." @default.
• W2912629617 created "2019-02-21" @default.
• W2912629617 creator A5014443035 @default.
• W2912629617 creator A5017173703 @default.
• W2912629617 creator A5018617711 @default.
• W2912629617 creator A5032202964 @default.
• W2912629617 creator A5057352924 @default.
• W2912629617 creator A5076458805 @default.
• W2912629617 date "2019-03-15" @default.
• W2912629617 modified "2023-10-16" @default.
• W2912629617 title "Effects of<scp>HIV</scp>‐1 Tat on oligodendrocyte viability are mediated by Ca<scp>MKII</scp>β–<scp>GSK</scp>3β interactions" @default.
• W2912629617 cites W1524845305 @default.
• W2912629617 cites W1581091695 @default.
• W2912629617 cites W1913367972 @default.
• W2912629617 cites W1969443674 @default.
• W2912629617 cites W1970750603 @default.
• W2912629617 cites W1972343960 @default.
• W2912629617 cites W1973115149 @default.
• W2912629617 cites W1975095798 @default.
• W2912629617 cites W1976362010 @default.
• W2912629617 cites W1980587324 @default.
• W2912629617 cites W1982069473 @default.
• W2912629617 cites W1982958012 @default.
• W2912629617 cites W1985096210 @default.
• W2912629617 cites W1992255165 @default.
• W2912629617 cites W1995794370 @default.
• W2912629617 cites W1996313489 @default.
• W2912629617 cites W1999272226 @default.
• W2912629617 cites W2021311192 @default.
• W2912629617 cites W2029643611 @default.
• W2912629617 cites W2032715957 @default.
• W2912629617 cites W2033217413 @default.
• W2912629617 cites W2033844584 @default.
• W2912629617 cites W2039363610 @default.
• W2912629617 cites W2040101760 @default.
• W2912629617 cites W2044127630 @default.
• W2912629617 cites W2046033738 @default.
• W2912629617 cites W2054275187 @default.
• W2912629617 cites W2058334021 @default.
• W2912629617 cites W2079335891 @default.
• W2912629617 cites W2084627994 @default.
• W2912629617 cites W2085663173 @default.
• W2912629617 cites W2088618997 @default.
• W2912629617 cites W2090849482 @default.
• W2912629617 cites W2092563800 @default.
• W2912629617 cites W2094836461 @default.
• W2912629617 cites W2095832516 @default.
• W2912629617 cites W2100290637 @default.
• W2912629617 cites W2102789443 @default.
• W2912629617 cites W2110904803 @default.
• W2912629617 cites W2113466274 @default.
• W2912629617 cites W2114091391 @default.
• W2912629617 cites W2115094443 @default.
• W2912629617 cites W2118444707 @default.
• W2912629617 cites W2121035637 @default.
• W2912629617 cites W2123834332 @default.
• W2912629617 cites W2132296918 @default.
• W2912629617 cites W2132406439 @default.
• W2912629617 cites W2136019899 @default.
• W2912629617 cites W2137321682 @default.
• W2912629617 cites W2156734918 @default.
• W2912629617 cites W2158096469 @default.
• W2912629617 cites W2163499365 @default.
• W2912629617 cites W2332670321 @default.
• W2912629617 cites W2369185249 @default.
• W2912629617 cites W2414707493 @default.
• W2912629617 cites W2614327605 @default.
• W2912629617 cites W2771282955 @default.
• W2912629617 cites W2803937104 @default.
• W2912629617 cites W2806890793 @default.
• W2912629617 cites W2901935247 @default.
• W2912629617 cites W3016885524 @default.
• W2912629617 cites W79896692 @default.
• W2912629617 doi "https://doi.org/10.1111/jnc.14668" @default.
• W2912629617 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6438763" @default.
• W2912629617 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30674062" @default.
• W2912629617 hasPublicationYear "2019" @default.
• W2912629617 type Work @default.
• W2912629617 sameAs 2912629617 @default.
• W2912629617 citedByCount "15" @default.
• W2912629617 countsByYear W29126296172019 @default.
• W2912629617 countsByYear W29126296172020 @default.
• W2912629617 countsByYear W29126296172021 @default.
• W2912629617 countsByYear W29126296172022 @default.
• W2912629617 countsByYear W29126296172023 @default.
• W2912629617 crossrefType "journal-article" @default.
• W2912629617 hasAuthorship W2912629617A5014443035 @default.
• W2912629617 hasAuthorship W2912629617A5017173703 @default.
• W2912629617 hasAuthorship W2912629617A5018617711 @default.
• W2912629617 hasAuthorship W2912629617A5032202964 @default.
• W2912629617 hasAuthorship W2912629617A5057352924 @default.
• W2912629617 hasAuthorship W2912629617A5076458805 @default.
• W2912629617 hasBestOaLocation W29126296171 @default.
• W2912629617 hasConcept C104629339 @default.
• W2912629617 hasConcept C182996813 @default.
• W2912629617 hasConcept C184235292 @default.
• W2912629617 hasConcept C190283241 @default.
• W2912629617 hasConcept C53227056 @default.

• next