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- W2912630198 abstract "Background: Aggressive periodontitis disease is a severe type of periodontal disease, which is characterized by enormous destruction of periodontal attachment and alveolar bone. A few loci have shown to be associated with aggressive periodontitis, which suggest a multifactorial genetic component. BRINP3 locus shows correlation with aggressive periodontitis.Aims: To replicate the initial findings of the relationship between aggressive periodontitis and BRINP3 genetic variation (rs1342913) in group of Arab subjects.Methods: 263 subjects were diagnosed with aggressive periodontitis. They are originally from Syria and Morocco. They are divided into: diseased (with aggressive periodontitis n= 200. Among them 49 from Syria and 151 from Morocco). and healthy (without aggressive periodontitis n= 63). Saliva was collected, then genomic DNA was extracted. One genetic marker was genotyped (BRINP3 rs1342913). PCR was run with TaqMan chemistry. Chi-square with alpha of 0.05 was utilized to test over-representation of genotypes or alleles between two groups.Result: The frequency AA genotype is higher than GG genotype. No significant difference between allele A and allele G.Conclusion: The frequency BRINP3 is higher in aggressive periodontitis compared with healthy cases in Arab population. Based on this result, BRINP3 gene is associated with aggressive periodontists." @default.
- W2912630198 created "2019-02-21" @default.
- W2912630198 creator A5045940774 @default.
- W2912630198 date "2018-07-30" @default.
- W2912630198 modified "2023-09-27" @default.
- W2912630198 title "Association Between BRINP3 Genetic Variation and Aggressive Periodontitis Among Arab Descents." @default.
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