FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912631529> ?p ?o ?g. }

• W2912631529 endingPage "95" @default.
• W2912631529 startingPage "39" @default.
• W2912631529 abstract "Leishmaniasis is causing a major health problem worldwide and only five to six drugs are available for its control. Among them, antimonials, amphotericin, and miltefosine have been introduced starting in the 1940s and have proved to be effective for many years. However, the appearance of resistance threatens the success of anti-Leishmania treatment and spontaneous resistance to classical first- and second-line anti-Leishmania therapy reveals the major need to develop novel and less toxic drugs. A deep understanding of the mechanisms of drug resistance may help in the design of novel anti-Leishmania agents to be exploited in combination or as second-line therapy. Moreover, the discovery and validation of novel and druggable targets represent a useful tool to tackle drug resistance in leishmaniasis. Some biological processes such as redox metabolism, folate biosynthesis, protein synthesis, and turnover are potentially suitable to develop novel effective agents since they involve proteins showing a unique biological profile with respect to the human metabolism. Phenotypic screening and target-based drug discovery are promising tools to be exploited in drug discovery and development for leishmaniasis. Herein, we outline the most recent efforts in the identification of novel chemical scaffolds using both drug discovery strategies. We finally discuss the breakthroughs in the identification and validation of new biological targets, including Leishmania infantum initiation factor 4A, Leishmania casein kinase 1.2 (LmCK1.2), and methionyl-tRNA synthetase in Leishmania parasites. Different medicinal chemistry teams are currently exploring these targets aiming to pick out compounds displaying an improved profile to reinforce the drug pipeline." @default.
• W2912631529 created "2019-02-21" @default.
• W2912631529 creator A5001825823 @default.
• W2912631529 creator A5005943895 @default.
• W2912631529 creator A5035521326 @default.
• W2912631529 creator A5067318892 @default.
• W2912631529 creator A5073099287 @default.
• W2912631529 creator A5080872827 @default.
• W2912631529 creator A5086565347 @default.
• W2912631529 date "2018-01-01" @default.
• W2912631529 modified "2023-09-26" @default.
• W2912631529 title "Chapter Two - Scaffolds and Biological Targets Avenue to Fight Against Drug Resistance in Leishmaniasis" @default.
• W2912631529 hasPublicationYear "2018" @default.
• W2912631529 type Work @default.
• W2912631529 sameAs 2912631529 @default.
• W2912631529 citedByCount "0" @default.
• W2912631529 crossrefType "journal-article" @default.
• W2912631529 hasAuthorship W2912631529A5001825823 @default.
• W2912631529 hasAuthorship W2912631529A5005943895 @default.
• W2912631529 hasAuthorship W2912631529A5035521326 @default.
• W2912631529 hasAuthorship W2912631529A5067318892 @default.
• W2912631529 hasAuthorship W2912631529A5073099287 @default.
• W2912631529 hasAuthorship W2912631529A5080872827 @default.
• W2912631529 hasAuthorship W2912631529A5086565347 @default.
• W2912631529 hasConcept C104317684 @default.
• W2912631529 hasConcept C10679952 @default.
• W2912631529 hasConcept C114851261 @default.
• W2912631529 hasConcept C136764020 @default.
• W2912631529 hasConcept C203014093 @default.
• W2912631529 hasConcept C2776114741 @default.
• W2912631529 hasConcept C2776555147 @default.
• W2912631529 hasConcept C2777787772 @default.
• W2912631529 hasConcept C2778689377 @default.
• W2912631529 hasConcept C2778702967 @default.
• W2912631529 hasConcept C2780035454 @default.
• W2912631529 hasConcept C2781092759 @default.
• W2912631529 hasConcept C2781257258 @default.
• W2912631529 hasConcept C2781417161 @default.
• W2912631529 hasConcept C41008148 @default.
• W2912631529 hasConcept C501593827 @default.
• W2912631529 hasConcept C55493867 @default.
• W2912631529 hasConcept C60644358 @default.
• W2912631529 hasConcept C70721500 @default.
• W2912631529 hasConcept C71928629 @default.
• W2912631529 hasConcept C74187038 @default.
• W2912631529 hasConcept C86803240 @default.
• W2912631529 hasConcept C89423630 @default.
• W2912631529 hasConcept C98274493 @default.
• W2912631529 hasConceptScore W2912631529C104317684 @default.
• W2912631529 hasConceptScore W2912631529C10679952 @default.
• W2912631529 hasConceptScore W2912631529C114851261 @default.
• W2912631529 hasConceptScore W2912631529C136764020 @default.
• W2912631529 hasConceptScore W2912631529C203014093 @default.
• W2912631529 hasConceptScore W2912631529C2776114741 @default.
• W2912631529 hasConceptScore W2912631529C2776555147 @default.
• W2912631529 hasConceptScore W2912631529C2777787772 @default.
• W2912631529 hasConceptScore W2912631529C2778689377 @default.
• W2912631529 hasConceptScore W2912631529C2778702967 @default.
• W2912631529 hasConceptScore W2912631529C2780035454 @default.
• W2912631529 hasConceptScore W2912631529C2781092759 @default.
• W2912631529 hasConceptScore W2912631529C2781257258 @default.
• W2912631529 hasConceptScore W2912631529C2781417161 @default.
• W2912631529 hasConceptScore W2912631529C41008148 @default.
• W2912631529 hasConceptScore W2912631529C501593827 @default.
• W2912631529 hasConceptScore W2912631529C55493867 @default.
• W2912631529 hasConceptScore W2912631529C60644358 @default.
• W2912631529 hasConceptScore W2912631529C70721500 @default.
• W2912631529 hasConceptScore W2912631529C71928629 @default.
• W2912631529 hasConceptScore W2912631529C74187038 @default.
• W2912631529 hasConceptScore W2912631529C86803240 @default.
• W2912631529 hasConceptScore W2912631529C89423630 @default.
• W2912631529 hasConceptScore W2912631529C98274493 @default.
• W2912631529 hasIssue "51" @default.
• W2912631529 hasLocation W29126315291 @default.
• W2912631529 hasOpenAccess W2912631529 @default.
• W2912631529 hasPrimaryLocation W29126315291 @default.
• W2912631529 hasRelatedWork W1938528392 @default.
• W2912631529 hasRelatedWork W1983956209 @default.
• W2912631529 hasRelatedWork W2027204839 @default.
• W2912631529 hasRelatedWork W2043482213 @default.
• W2912631529 hasRelatedWork W2056529056 @default.
• W2912631529 hasRelatedWork W2159394058 @default.
• W2912631529 hasRelatedWork W2262786583 @default.
• W2912631529 hasRelatedWork W2409686421 @default.
• W2912631529 hasRelatedWork W2761408147 @default.
• W2912631529 hasRelatedWork W2794096376 @default.
• W2912631529 hasRelatedWork W2801705253 @default.
• W2912631529 hasRelatedWork W2805346684 @default.
• W2912631529 hasRelatedWork W2894270215 @default.
• W2912631529 hasRelatedWork W2899421184 @default.
• W2912631529 hasRelatedWork W2903383142 @default.
• W2912631529 hasRelatedWork W3033545876 @default.
• W2912631529 hasRelatedWork W3107079081 @default.
• W2912631529 hasRelatedWork W3133555557 @default.
• W2912631529 hasRelatedWork W3158571410 @default.
• W2912631529 hasRelatedWork W3205911621 @default.
• W2912631529 isParatext "false" @default.
• W2912631529 isRetracted "false" @default.

• next