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• W2912631937 startingPage "83" @default.
• W2912631937 abstract "In recent years, much attention is focused on silver nanoparticles for biomedical applications and then synthesis using plant procedure has drawn a great focus. In the current study silver nanoparticles were synthesized using the oil cake of Sesamumindicum, which has been used traditionally for several therapeutic purposes. Silver nanoparticles (NPs) were synthesizedin the presence of sesame oil cake. The sesame oil cake facilitated the biosynthesis of silver nanoparticles (SCAgNPs). The synthesized SCAgNPs were subjected to several studies using UV-Visspectroscopy, FTIR, XRD, TEM, and EDS and the particle characteristics were confirmed. The synthesized SCAgNPs was tested for antimicrobial activity using the disk diffusion method. The antitumor activity of the synthesized SCAgNPs was also tested usingbreast cancer cell lines (MCF-7). TEM result revealed spherical shape with a diameter ranging from 6.6 nm to 14.8 nm. Presence of elemental silver in the prepared SCAgNPs was confirmed by EDS. Further a cytotoxicity study was done on two different concentrations of SCAgNPs (2.5 and 7.5 μg/mL) on human breastcancer cell line (MCF-7 cells). Initially, 2.5 μg/mL dose treatment showed a viable cells region of 72.02%, apoptosis 11.81%; late apoptosis 15.18% and necrosis 1.20%. Interestingly, 7.5 μg/mL exhibited substantial cytotoxic effects, viable cells region 56.97%, apoptosis 7.42%, late apoptosis 31.19% and necrosis 4.85%. In the control, viable cells region was 73.72%, apoptosis 10.82%, late apoptosis 14.54% and necrosis 1.58%. The minimum inhibitory concentration (0.5 μg/mL), study was done on P. aeruginosa (27853), K. pneumoniae (70063), E. coli (25922). Silver nanoparticles synthesized using sesame oil cake exhibited a good antibacterial and antitumor activity. Hence it's a first report to spell out the therapeutic effect of AgNPs of sesame oil cake origin." @default.
• W2912631937 created "2019-02-21" @default.
• W2912631937 creator A5000969052 @default.
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• W2912631937 date "2019-03-01" @default.
• W2912631937 modified "2023-10-12" @default.
• W2912631937 title "Eco-friendly green synthesis of silver nanoparticles from the sesame oil cake and its potential anticancer and antimicrobial activities" @default.
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• W2912631937 doi "https://doi.org/10.1016/j.jphotobiol.2019.01.011" @default.
• W2912631937 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30710829" @default.
• W2912631937 hasPublicationYear "2019" @default.
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