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- W2912631995 abstract "Farm exposure in infancy is associated with a decreased risk of atopic disease, possibly due to different patterns of microbial colonization. We hypothesize that the gut microbiome of infants raised on farms will differ from the gut microbiome of infants not exposed to farms. In the Wisconsin Infant Study Cohort (WISC), stool specimens were collected at age 2 months from 94 infants from farm families and 110 infants from non-farm families. High-quality 16S rRNA biomarker profiles were obtained from 89 farm and 102 non-farm infants and statistical analyses were performed in R. Gut microbiota of infants raised in farming versus non-farming environments differed significantly but explained only a small proportion of microbiota compositional variance (Unweighted UniFrac: R2=0.008, P=0.003). Consistent with this observation, six bacterial taxa were differentially enriched (FDR adjusted p<0.2): Clostridiaceae, Akkermansia, and Blautia members were increased in relative abundance in the stool of farm infants, while Veillonella, Bifidobacterium, and Clostridium members were relatively increased in non-farm infants. The gut microbiota of infants raised on a farm have specific distinct taxonomic features. Members of the bacterial genera Akkermansia and Clostridia enriched in farm infants are also enriched in urban infants at lower risk of atopy and asthma development. They are known to reduce inflammation via gut microbiome restructuring and, in the case of Clostridia, via short chain fatty acid production. The differences in neonatal gut microbiome warrant further investigation to delineate how specific early life exposures might modify the gut microbiome to reduce atopic disease." @default.
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- W2912631995 date "2019-02-01" @default.
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- W2912631995 title "Evaluating the Effects of Farm Exposure on Infant Gut Microbiome" @default.
- W2912631995 doi "https://doi.org/10.1016/j.jaci.2018.12.911" @default.
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