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- W2912634576 abstract "Abstract The β-neurotoxic secreted phospholipases A 2 (sPLA 2 s) block neuro-muscular transmission by poisoning nerve terminals. Damage inflicted by such sPLA 2 s (β-ntx) on neuronal mitochondria is characteristic, very similar to that induced by structurally homologous endogenous group IIA sPLA 2 when its activity is elevated, as, for example, in the early phase of Alzheimer’s disease. Using ammodytoxin (Atx), the β-ntx from the venom of the nose-horned viper ( Vipera a . ammodytes ), the sPLA 2 receptor R25 has been detected in neuronal mitochondria. This receptor has been purified from porcine cerebral cortex mitochondria by a new Atx-affinity-based chromatographic procedure. Mass spectrometry analysis revealed R25 to be the subunit II of cytochrome c oxidase (CCOX), an essential constituent of the respiratory chain complex. CCOX was confirmed as being the first intracellular membrane receptor for sPLA 2 by alternative Atx-affinity-labellings of purified CCOX, supported also by the encounter of Atx and CCOX in PC12 cells. This discovery suggests the explanation of the mechanism by which β-ntx hinders production of ATP in poisoned nerve endings. It also provides a new insight into the potential function and dysfunction of endogenous GIIA sPLA 2 in mitochondria." @default.
- W2912634576 created "2019-02-21" @default.
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- W2912634576 date "2019-01-22" @default.
- W2912634576 modified "2023-10-16" @default.
- W2912634576 title "The neurotoxic secreted phospholipase A2 from the Vipera a. ammodytes venom targets cytochrome c oxidase in neuronal mitochondria" @default.
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- W2912634576 doi "https://doi.org/10.1038/s41598-018-36461-6" @default.
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