Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912635732> ?p ?o ?g. }
- W2912635732 abstract "Satellite cells (SCs) are skeletal muscle stem cells that proliferate in response to injury and provide myogenic precursors for growth and repair. Zfp423 is a transcriptional cofactor expressed in multiple immature cell populations, such as neuronal precursors, mesenchymal stem cells, and preadipocytes, where it regulates lineage allocation, proliferation, and differentiation. Here, we show that Zfp423 regulates myogenic progression during muscle regeneration. Zfp423 is undetectable in quiescent SCs but becomes expressed during SC activation. After expansion, Zfp423 is gradually downregulated as committed SCs terminally differentiate. Mice with satellite-cell-specific Zfp423 deletion exhibit severely impaired muscle regeneration following injury, with aberrant SC expansion, defective cell cycle exit, and failure to transition efficiently from the proliferative stage toward commitment. Consistent with a cell-autonomous role of Zfp423, shRNA-mediated knockdown of Zfp423 in myoblasts inhibits differentiation. Surprisingly, forced expression of Zfp423 in myoblasts induces differentiation into adipocytes and arrests myogenesis. Affinity purification of Zfp423 in myoblasts identified Satb2 as a nuclear partner of Zfp423 that cooperatively enhances Zfp423 transcriptional activity, which in turn affects myoblast differentiation. In conclusion, by controlling SC expansion and proliferation, Zfp423 is essential for muscle regeneration. Tight regulation of Zfp423 expression is essential for normal progression of muscle progenitors from proliferation to differentiation." @default.
- W2912635732 created "2019-02-21" @default.
- W2912635732 creator A5025873467 @default.
- W2912635732 creator A5044160632 @default.
- W2912635732 creator A5046290174 @default.
- W2912635732 creator A5053072500 @default.
- W2912635732 creator A5066457998 @default.
- W2912635732 creator A5071603809 @default.
- W2912635732 creator A5075100407 @default.
- W2912635732 date "2019-04-01" @default.
- W2912635732 modified "2023-10-13" @default.
- W2912635732 title "Zfp423 Regulates Skeletal Muscle Regeneration and Proliferation" @default.
- W2912635732 cites W1485210967 @default.
- W2912635732 cites W1599501164 @default.
- W2912635732 cites W1845077221 @default.
- W2912635732 cites W1886106832 @default.
- W2912635732 cites W1964552609 @default.
- W2912635732 cites W1965982769 @default.
- W2912635732 cites W1967290608 @default.
- W2912635732 cites W1968251266 @default.
- W2912635732 cites W1968822620 @default.
- W2912635732 cites W1969122967 @default.
- W2912635732 cites W1977116914 @default.
- W2912635732 cites W1981067059 @default.
- W2912635732 cites W1981242420 @default.
- W2912635732 cites W1986595328 @default.
- W2912635732 cites W1994254900 @default.
- W2912635732 cites W1994340993 @default.
- W2912635732 cites W1997014674 @default.
- W2912635732 cites W1998118119 @default.
- W2912635732 cites W2001170778 @default.
- W2912635732 cites W2003098906 @default.
- W2912635732 cites W2010221831 @default.
- W2912635732 cites W2017075649 @default.
- W2912635732 cites W2020007904 @default.
- W2912635732 cites W2024181965 @default.
- W2912635732 cites W2028358008 @default.
- W2912635732 cites W2032326980 @default.
- W2912635732 cites W2037700340 @default.
- W2912635732 cites W2038657829 @default.
- W2912635732 cites W2040419432 @default.
- W2912635732 cites W2043251964 @default.
- W2912635732 cites W2044228161 @default.
- W2912635732 cites W2049193450 @default.
- W2912635732 cites W2049798884 @default.
- W2912635732 cites W2053712883 @default.
- W2912635732 cites W2063445980 @default.
- W2912635732 cites W2063612002 @default.
- W2912635732 cites W2067138320 @default.
- W2912635732 cites W2068636735 @default.
- W2912635732 cites W2070696494 @default.
- W2912635732 cites W2074814691 @default.
- W2912635732 cites W2083941402 @default.
- W2912635732 cites W2090535095 @default.
- W2912635732 cites W2096622475 @default.
- W2912635732 cites W2103140083 @default.
- W2912635732 cites W2104827888 @default.
- W2912635732 cites W2114340913 @default.
- W2912635732 cites W2115795860 @default.
- W2912635732 cites W2117317220 @default.
- W2912635732 cites W2122160273 @default.
- W2912635732 cites W2122795085 @default.
- W2912635732 cites W2123511906 @default.
- W2912635732 cites W2123661716 @default.
- W2912635732 cites W2135136881 @default.
- W2912635732 cites W2138779444 @default.
- W2912635732 cites W2142076945 @default.
- W2912635732 cites W2159999899 @default.
- W2912635732 cites W2160248324 @default.
- W2912635732 cites W2165615115 @default.
- W2912635732 cites W2170115375 @default.
- W2912635732 cites W2174172561 @default.
- W2912635732 cites W2467994580 @default.
- W2912635732 cites W2551774097 @default.
- W2912635732 cites W2556397577 @default.
- W2912635732 cites W2617623825 @default.
- W2912635732 cites W2754179787 @default.
- W2912635732 cites W2949915089 @default.
- W2912635732 cites W4235438234 @default.
- W2912635732 cites W4244095134 @default.
- W2912635732 doi "https://doi.org/10.1128/mcb.00447-18" @default.
- W2912635732 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6447414" @default.
- W2912635732 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30692273" @default.
- W2912635732 hasPublicationYear "2019" @default.
- W2912635732 type Work @default.
- W2912635732 sameAs 2912635732 @default.
- W2912635732 citedByCount "11" @default.
- W2912635732 countsByYear W29126357322020 @default.
- W2912635732 countsByYear W29126357322021 @default.
- W2912635732 countsByYear W29126357322022 @default.
- W2912635732 countsByYear W29126357322023 @default.
- W2912635732 crossrefType "journal-article" @default.
- W2912635732 hasAuthorship W2912635732A5025873467 @default.
- W2912635732 hasAuthorship W2912635732A5044160632 @default.
- W2912635732 hasAuthorship W2912635732A5046290174 @default.
- W2912635732 hasAuthorship W2912635732A5053072500 @default.
- W2912635732 hasAuthorship W2912635732A5066457998 @default.
- W2912635732 hasAuthorship W2912635732A5071603809 @default.
- W2912635732 hasAuthorship W2912635732A5075100407 @default.
- W2912635732 hasBestOaLocation W29126357321 @default.