Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912641337> ?p ?o ?g. }
- W2912641337 endingPage "3124" @default.
- W2912641337 startingPage "3116" @default.
- W2912641337 abstract "Objective: To identify microRNAs (miRNAs) differentially expressed in plasma exosomes collected in women diagnosed with preeclampsia compared with women with uncomplicated pregnancies.Materials and methods: Exosomes were purified from plasma samples obtained at each trimester from four women subsequently diagnosed with preeclampsia and from five matched healthy controls. RNA was purified from the exosomes, and expression of 368 miRNAs was profiled using A-Set TaqMan low density array (TLDA).Results: One-third of the 368 miRNAs profiled are not expressed in exosomes. Further, those that are not expressed tend to be evolutionarily younger and have a significantly different mature sequence signature than do miRNAs that are expressed in exosomes. Among miRNAs that are expressed in exosomes, a total of eight (miR-134, miR-196b, miR-302c, miR-346, miR-376c, miR-486-3p, miR-590-5p, and miR-618) were found to display statistically significant differential expression between women who developed preeclampsia as compared with those who did not. Moreover, half of these miRNAs (miR-134, miR-376c, miR-486-3p, and miR-590-5p) displayed statistically significant differential expression in the first trimester.Conclusions: Not all miRNAs are expressed in exosomes. Those that tend to be evolutionarily older and have a significantly different mature sequence signature than those that are not. A few exosome-expressed miRNAs do display expression patterns in women subsequently diagnosed with preeclampsia that are significantly different than in women having an uncomplicated and, among these, several appear in the first trimester. These miRNAs are potential early markers of preeclampsia risk." @default.
- W2912641337 created "2019-02-21" @default.
- W2912641337 creator A5010768926 @default.
- W2912641337 creator A5011911130 @default.
- W2912641337 creator A5015401066 @default.
- W2912641337 creator A5045245691 @default.
- W2912641337 creator A5060207054 @default.
- W2912641337 date "2019-01-30" @default.
- W2912641337 modified "2023-10-06" @default.
- W2912641337 title "Trimester-specific plasma exosome microRNA expression profiles in preeclampsia" @default.
- W2912641337 cites W1665517288 @default.
- W2912641337 cites W1840581595 @default.
- W2912641337 cites W1965098283 @default.
- W2912641337 cites W1973242253 @default.
- W2912641337 cites W1985579290 @default.
- W2912641337 cites W1985844219 @default.
- W2912641337 cites W1992022626 @default.
- W2912641337 cites W1992069272 @default.
- W2912641337 cites W1993474041 @default.
- W2912641337 cites W2004055816 @default.
- W2912641337 cites W2005154332 @default.
- W2912641337 cites W2014193833 @default.
- W2912641337 cites W2022495797 @default.
- W2912641337 cites W2026697437 @default.
- W2912641337 cites W2027779213 @default.
- W2912641337 cites W2042871312 @default.
- W2912641337 cites W2046517816 @default.
- W2912641337 cites W2048859550 @default.
- W2912641337 cites W2053664200 @default.
- W2912641337 cites W2057477277 @default.
- W2912641337 cites W2061506872 @default.
- W2912641337 cites W2066604609 @default.
- W2912641337 cites W2072449468 @default.
- W2912641337 cites W2072633789 @default.
- W2912641337 cites W2074216902 @default.
- W2912641337 cites W2077560715 @default.
- W2912641337 cites W2085982276 @default.
- W2912641337 cites W2105726520 @default.
- W2912641337 cites W2107277218 @default.
- W2912641337 cites W2109227959 @default.
- W2912641337 cites W2114570899 @default.
- W2912641337 cites W2116103062 @default.
- W2912641337 cites W2118330874 @default.
- W2912641337 cites W2120330692 @default.
- W2912641337 cites W2131840335 @default.
- W2912641337 cites W2138664009 @default.
- W2912641337 cites W2139214330 @default.
- W2912641337 cites W2139485309 @default.
- W2912641337 cites W2150949422 @default.
- W2912641337 cites W2153570621 @default.
- W2912641337 cites W2154882306 @default.
- W2912641337 cites W2158266834 @default.
- W2912641337 cites W2158485828 @default.
- W2912641337 cites W215906235 @default.
- W2912641337 cites W2160226189 @default.
- W2912641337 cites W2160467221 @default.
- W2912641337 cites W2163482204 @default.
- W2912641337 cites W2164012646 @default.
- W2912641337 cites W2168524173 @default.
- W2912641337 cites W2171062859 @default.
- W2912641337 cites W2171115585 @default.
- W2912641337 cites W2171945997 @default.
- W2912641337 cites W2519385241 @default.
- W2912641337 cites W2737039264 @default.
- W2912641337 cites W2737202258 @default.
- W2912641337 cites W2799277945 @default.
- W2912641337 cites W301622561 @default.
- W2912641337 doi "https://doi.org/10.1080/14767058.2019.1569614" @default.
- W2912641337 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7328825" @default.
- W2912641337 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30700172" @default.
- W2912641337 hasPublicationYear "2019" @default.
- W2912641337 type Work @default.
- W2912641337 sameAs 2912641337 @default.
- W2912641337 citedByCount "29" @default.
- W2912641337 countsByYear W29126413372019 @default.
- W2912641337 countsByYear W29126413372020 @default.
- W2912641337 countsByYear W29126413372021 @default.
- W2912641337 countsByYear W29126413372022 @default.
- W2912641337 countsByYear W29126413372023 @default.
- W2912641337 crossrefType "journal-article" @default.
- W2912641337 hasAuthorship W2912641337A5010768926 @default.
- W2912641337 hasAuthorship W2912641337A5011911130 @default.
- W2912641337 hasAuthorship W2912641337A5015401066 @default.
- W2912641337 hasAuthorship W2912641337A5045245691 @default.
- W2912641337 hasAuthorship W2912641337A5060207054 @default.
- W2912641337 hasBestOaLocation W29126413372 @default.
- W2912641337 hasConcept C104317684 @default.
- W2912641337 hasConcept C105580179 @default.
- W2912641337 hasConcept C119056186 @default.
- W2912641337 hasConcept C143660080 @default.
- W2912641337 hasConcept C145059251 @default.
- W2912641337 hasConcept C16685009 @default.
- W2912641337 hasConcept C203014093 @default.
- W2912641337 hasConcept C20518536 @default.
- W2912641337 hasConcept C2777218350 @default.
- W2912641337 hasConcept C2779234561 @default.
- W2912641337 hasConcept C2781261824 @default.
- W2912641337 hasConcept C48023723 @default.