FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912641357> ?p ?o ?g. }

• W2912641357 endingPage "675" @default.
• W2912641357 startingPage "661" @default.
• W2912641357 abstract "Hypoxic zones are common features of metastatic tumors. Due to inactivation of the von Hippel-Lindau gene (VHL), renal cell carcinomas (RCC) show constitutive stabilization of the alpha subunit of the hypoxia-inducible factor (HIF). Thus, RCC represents a model of chronic hypoxia. Development of the lymphatic network is dependent on vascular endothelial growth factor C (VEGFC) and lies at the front line of metastatic spreading. Here, we addressed the role of VEGFC in RCC aggressiveness and the regulation of its expression in hypoxia. Methods: Transcriptional and post transcriptional regulation of VEGFC expression was evaluated by qPCR and with reporter genes. The involvement of HIF was evaluated using a siRNA approach. Experimental RCC were performed with immuno-competent/deficient mice using human and mouse cells knocked-out for the VEGFC gene by a CRISPR/Cas9 method. The VEGFC axis was analyzed with an online available data base (TCGA) and using an independent cohort of patients. Results: Hypoxia induced VEGFC protein expression but down-regulated VEGFC gene transcription and mRNA stability. Increased proliferation, migration, over-activation of the AKT signaling pathway and enhanced expression of mesenchymal markers characterized VEGFC-/- cells. VEGFC-/- cells did not form tumors in immuno-deficient mice but developed aggressive tumors in immuno-competent mice. These tumors showed down-regulation of markers of activated lymphocytes and M1 macrophages, and up-regulation of M2 macrophages markers and programmed death ligand 1 (PDL1). Over-expression of lymphangiogenic genes including VEGFC was linked to increased disease-free and overall survival in patients with non-metastatic tumors, whereas its over-expression correlated with decreased progression-free and overall survival of metastatic patients. Conclusion: Our study revisited the admitted dogma linking VEGFC to tumor aggressiveness. We conclude that targeting VEGFC for therapy must be considered with caution." @default.
• W2912641357 created "2019-02-21" @default.
• W2912641357 creator A5004541246 @default.
• W2912641357 creator A5011513530 @default.
• W2912641357 creator A5015978447 @default.
• W2912641357 creator A5017594953 @default.
• W2912641357 creator A5029475255 @default.
• W2912641357 creator A5029548411 @default.
• W2912641357 creator A5034773695 @default.
• W2912641357 creator A5037025946 @default.
• W2912641357 creator A5039094119 @default.
• W2912641357 creator A5040053100 @default.
• W2912641357 creator A5045396112 @default.
• W2912641357 creator A5046085675 @default.
• W2912641357 creator A5046991850 @default.
• W2912641357 creator A5049425103 @default.
• W2912641357 creator A5051357513 @default.
• W2912641357 creator A5090083053 @default.
• W2912641357 date "2019-01-01" @default.
• W2912641357 modified "2023-10-13" @default.
• W2912641357 title "VEGFC acts as a double-edged sword in renal cell carcinoma aggressiveness" @default.
• W2912641357 cites W1564728191 @default.
• W2912641357 cites W1759375471 @default.
• W2912641357 cites W1905242869 @default.
• W2912641357 cites W1964847767 @default.
• W2912641357 cites W1967152628 @default.
• W2912641357 cites W1967600348 @default.
• W2912641357 cites W1969963445 @default.
• W2912641357 cites W1977709885 @default.
• W2912641357 cites W1984804749 @default.
• W2912641357 cites W1994300159 @default.
• W2912641357 cites W1996715681 @default.
• W2912641357 cites W2003454386 @default.
• W2912641357 cites W2003794908 @default.
• W2912641357 cites W2005467912 @default.
• W2912641357 cites W2012062654 @default.
• W2912641357 cites W2016054079 @default.
• W2912641357 cites W2020411799 @default.
• W2912641357 cites W2031248825 @default.
• W2912641357 cites W2033372592 @default.
• W2912641357 cites W2044835625 @default.
• W2912641357 cites W2046025486 @default.
• W2912641357 cites W2047331328 @default.
• W2912641357 cites W2061257207 @default.
• W2912641357 cites W2062244504 @default.
• W2912641357 cites W2067121396 @default.
• W2912641357 cites W2069225985 @default.
• W2912641357 cites W2070156564 @default.
• W2912641357 cites W2071881303 @default.
• W2912641357 cites W2073535977 @default.
• W2912641357 cites W2094518946 @default.
• W2912641357 cites W2097731330 @default.
• W2912641357 cites W2103176225 @default.
• W2912641357 cites W2106102605 @default.
• W2912641357 cites W2114843025 @default.
• W2912641357 cites W2116949558 @default.
• W2912641357 cites W2118677643 @default.
• W2912641357 cites W2135387190 @default.
• W2912641357 cites W2137193118 @default.
• W2912641357 cites W2140088548 @default.
• W2912641357 cites W2149163652 @default.
• W2912641357 cites W2149441684 @default.
• W2912641357 cites W2152829361 @default.
• W2912641357 cites W2154386948 @default.
• W2912641357 cites W2154840175 @default.
• W2912641357 cites W2158535498 @default.
• W2912641357 cites W2160202883 @default.
• W2912641357 cites W2160724351 @default.
• W2912641357 cites W2166788033 @default.
• W2912641357 cites W2206853573 @default.
• W2912641357 cites W2222086386 @default.
• W2912641357 cites W2237254160 @default.
• W2912641357 cites W2339442385 @default.
• W2912641357 cites W2463811993 @default.
• W2912641357 cites W2510079645 @default.
• W2912641357 cites W2521838781 @default.
• W2912641357 cites W2555008614 @default.
• W2912641357 cites W2579645887 @default.
• W2912641357 cites W2625086811 @default.
• W2912641357 cites W2725271626 @default.
• W2912641357 cites W2753159186 @default.
• W2912641357 cites W2792937256 @default.
• W2912641357 cites W999922911 @default.
• W2912641357 doi "https://doi.org/10.7150/thno.27794" @default.
• W2912641357 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6376471" @default.
• W2912641357 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30809300" @default.
• W2912641357 hasPublicationYear "2019" @default.
• W2912641357 type Work @default.
• W2912641357 sameAs 2912641357 @default.
• W2912641357 citedByCount "18" @default.
• W2912641357 countsByYear W29126413572020 @default.
• W2912641357 countsByYear W29126413572021 @default.
• W2912641357 countsByYear W29126413572022 @default.
• W2912641357 countsByYear W29126413572023 @default.
• W2912641357 crossrefType "journal-article" @default.
• W2912641357 hasAuthorship W2912641357A5004541246 @default.
• W2912641357 hasAuthorship W2912641357A5011513530 @default.
• W2912641357 hasAuthorship W2912641357A5015978447 @default.

• next