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• W2912642594 abstract "Purpose To evaluate the ultrasound (US) response in patients with breast cancer (BC) during neoadjuvant chemotherapy (NAC). Methods Prospective US analysis was performed on 19 malignant tumors prior to NAC treatment and 7 days after each first four courses of NAC in 13 patients (median age = 57 years). Echogenicity, size, vascularity, and sonoelastography were measured and compared with posttreatment scores of residual cancers burden. Results Changes in the echogenicity of tumors after 3 courses of NAC had the most statistically strong correlation with the percentage of residual malignant cells used in histopathology to assess the response to treatment (odds ratio = 60, p < 0.05). Changes in lesion size and elasticity were also significant (p < 0.05). Conclusions There is a statistically significant relationship between breast tumors' echogenicity in US, neoplasm size, and stiffness and the response to NAC. In particular, our results show that the change in tumor echogenicity could predict a pathological response with satisfactory accuracy and may be considered in NAC monitoring." @default.
• W2912642594 created "2019-02-21" @default.
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• W2912642594 date "2019-05-01" @default.
• W2912642594 modified "2023-09-30" @default.
• W2912642594 title "Ultrasound echogenicity reveals the response of breast cancer to chemotherapy" @default.
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• W2912642594 doi "https://doi.org/10.1016/j.clinimag.2019.01.021" @default.
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