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• W2912643140 abstract "Clostridium perfringens type F enteric diseases, which include a very common form of food poisoning and many cases of antibiotic-associated diarrhea, develop when type F strains sporulate and produce C. perfringens enterotoxin (CPE) in the intestines. Spores are also important for transmission of type F disease. Despite the importance of sporulation for type F disease and the evidence that C. perfringens sporulation begins with phosphorylation of the Spo0A transcriptional regulator, the kinase phosphorylating Spo0A to initiate sporulation and CPE production had not been ascertained. In response, the current report now provides identification of an orphan histidine kinase named CPR0195 that can directly phosphorylate Spo0A. Results using a CPR0195 null mutant indicate that this kinase is very important for initiating C. perfringens sporulation and CPE production. Therefore, the CPR0195 kinase represents a potential target to block type F disease by interfering with intestinal C. perfringens sporulation and CPE production." @default.
• W2912643140 created "2019-02-21" @default.
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• W2912643140 date "2019-02-26" @default.
• W2912643140 modified "2023-10-16" @default.
• W2912643140 title "Identification of an Important Orphan Histidine Kinase for the Initiation of Sporulation and Enterotoxin Production by <i>Clostridium perfringens</i> Type F Strain SM101" @default.
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• W2912643140 doi "https://doi.org/10.1128/mbio.02674-18" @default.
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