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- W2912643812 abstract "Sensitive yet rapid methods for detection of rare earth elements (REEs), including lanthanides (Lns), would facilitate mining and recycling of these elements. Here we report a highly selective, genetically encoded fluorescent sensor for Lns, LaMP1, based on the recently characterized protein, lanmodulin. LaMP1 displays a 7-fold ratiometric response to all LnIIIs, with apparent Kds of 10-50 pM but only weak response to other common divalent and trivalent metal ions. We use LaMP1 to demonstrate for the first time that a Ln-utilizing bacterium, Methylobacterium extorquens, selectively transports early Lns (LaIII-NdIII) into its cytosol, a surprising observation as the only Ln-proteins identified to date are periplasmic. Finally, we apply LaMP1 to suggest the existence of a LnIII uptake system utilizing a secreted metal chelator, akin to siderophore-mediated FeIII acquisition. LaMP1 not only sheds light on Ln biology but also may be a useful technology for detecting and quantifying REEs in environmental and industrial samples." @default.
- W2912643812 created "2019-02-21" @default.
- W2912643812 creator A5058023900 @default.
- W2912643812 creator A5065803066 @default.
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- W2912643812 date "2019-02-06" @default.
- W2912643812 modified "2023-10-13" @default.
- W2912643812 title "A Selective, Protein-Based Fluorescent Sensor with Picomolar Affinity for Rare Earth Elements" @default.
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- W2912643812 doi "https://doi.org/10.1021/jacs.8b12155" @default.
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