FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912643970> ?p ?o ?g. }

• W2912643970 endingPage "375" @default.
• W2912643970 startingPage "370" @default.
• W2912643970 abstract "Serotonin (5-HT) is a major neurotransmitter in mammalian brains and is involved in brain development and psychiatric disorders. The 5-HT1A receptor (5-HT1AR) is a G-protein-coupled receptor (GPCR) associated with an inhibitory G-protein (Gi) with the widest and most abundant expression. It is not known; however, how expression or activity of 5-HTlAR is regulated. We studied here phosphorylation of 5-HT1AR by cyclin-dependent kinase 5 (Cdk5), a neuron-specific membrane-bound Ser/Thr kinase that is activated by binding of the p35 Cdk5 activator. 5-HT1AR was phosphorylated by the Cdk5–p35 complex at Thr314 in the third cytoplasmic loop. The phosphorylation stimulated the degradation of 5-HT1AR by the proteasome, resulting in neutralization of the inhibitory action of 5-HT1AR on intracellular cAMP concentration. These results suggest that Cdk5–p35 modulates 5-HT signaling through phosphorylation-dependent degradation of 5-HTlAR." @default.
• W2912643970 created "2019-02-21" @default.
• W2912643970 creator A5031696916 @default.
• W2912643970 creator A5055594949 @default.
• W2912643970 creator A5074083936 @default.
• W2912643970 creator A5077045599 @default.
• W2912643970 creator A5079033274 @default.
• W2912643970 date "2019-03-01" @default.
• W2912643970 modified "2023-09-25" @default.
• W2912643970 title "Cyclin-dependent kinase 5 promotes proteasomal degradation of the 5-HT1A receptor via phosphorylation" @default.
• W2912643970 cites W1529020147 @default.
• W2912643970 cites W1548004443 @default.
• W2912643970 cites W1971468364 @default.
• W2912643970 cites W1973383826 @default.
• W2912643970 cites W1973883347 @default.
• W2912643970 cites W1996198347 @default.
• W2912643970 cites W2004176156 @default.
• W2912643970 cites W2011469597 @default.
• W2912643970 cites W2011573205 @default.
• W2912643970 cites W2014711343 @default.
• W2912643970 cites W2015265007 @default.
• W2912643970 cites W2021958350 @default.
• W2912643970 cites W2022410893 @default.
• W2912643970 cites W2028559822 @default.
• W2912643970 cites W2039530860 @default.
• W2912643970 cites W2042022467 @default.
• W2912643970 cites W2043368216 @default.
• W2912643970 cites W2063374762 @default.
• W2912643970 cites W2068009600 @default.
• W2912643970 cites W2071179637 @default.
• W2912643970 cites W2087654725 @default.
• W2912643970 cites W2098331502 @default.
• W2912643970 cites W2098732177 @default.
• W2912643970 cites W2101205908 @default.
• W2912643970 cites W2119205557 @default.
• W2912643970 cites W2129866123 @default.
• W2912643970 cites W2146950700 @default.
• W2912643970 cites W2162583663 @default.
• W2912643970 cites W2166973704 @default.
• W2912643970 cites W2560573672 @default.
• W2912643970 cites W2744402516 @default.
• W2912643970 cites W2753654430 @default.
• W2912643970 cites W2782430004 @default.
• W2912643970 cites W2904487322 @default.
• W2912643970 doi "https://doi.org/10.1016/j.bbrc.2019.01.093" @default.
• W2912643970 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30712943" @default.
• W2912643970 hasPublicationYear "2019" @default.
• W2912643970 type Work @default.
• W2912643970 sameAs 2912643970 @default.
• W2912643970 citedByCount "4" @default.
• W2912643970 countsByYear W29126439702020 @default.
• W2912643970 countsByYear W29126439702022 @default.
• W2912643970 countsByYear W29126439702023 @default.
• W2912643970 crossrefType "journal-article" @default.
• W2912643970 hasAuthorship W2912643970A5031696916 @default.
• W2912643970 hasAuthorship W2912643970A5055594949 @default.
• W2912643970 hasAuthorship W2912643970A5074083936 @default.
• W2912643970 hasAuthorship W2912643970A5077045599 @default.
• W2912643970 hasAuthorship W2912643970A5079033274 @default.
• W2912643970 hasBestOaLocation W29126439701 @default.
• W2912643970 hasConcept C11960822 @default.
• W2912643970 hasConcept C121738310 @default.
• W2912643970 hasConcept C170493617 @default.
• W2912643970 hasConcept C184235292 @default.
• W2912643970 hasConcept C185592680 @default.
• W2912643970 hasConcept C2779933727 @default.
• W2912643970 hasConcept C55493867 @default.
• W2912643970 hasConcept C82495950 @default.
• W2912643970 hasConcept C86803240 @default.
• W2912643970 hasConcept C88045685 @default.
• W2912643970 hasConcept C95444343 @default.
• W2912643970 hasConcept C97029542 @default.
• W2912643970 hasConceptScore W2912643970C11960822 @default.
• W2912643970 hasConceptScore W2912643970C121738310 @default.
• W2912643970 hasConceptScore W2912643970C170493617 @default.
• W2912643970 hasConceptScore W2912643970C184235292 @default.
• W2912643970 hasConceptScore W2912643970C185592680 @default.
• W2912643970 hasConceptScore W2912643970C2779933727 @default.
• W2912643970 hasConceptScore W2912643970C55493867 @default.
• W2912643970 hasConceptScore W2912643970C82495950 @default.
• W2912643970 hasConceptScore W2912643970C86803240 @default.
• W2912643970 hasConceptScore W2912643970C88045685 @default.
• W2912643970 hasConceptScore W2912643970C95444343 @default.
• W2912643970 hasConceptScore W2912643970C97029542 @default.
• W2912643970 hasFunder F4320320912 @default.
• W2912643970 hasIssue "3" @default.
• W2912643970 hasLocation W29126439701 @default.
• W2912643970 hasLocation W29126439702 @default.
• W2912643970 hasOpenAccess W2912643970 @default.
• W2912643970 hasPrimaryLocation W29126439701 @default.
• W2912643970 hasRelatedWork W1640595204 @default.
• W2912643970 hasRelatedWork W1745050920 @default.
• W2912643970 hasRelatedWork W1977381318 @default.
• W2912643970 hasRelatedWork W2025794474 @default.
• W2912643970 hasRelatedWork W2056791505 @default.
• W2912643970 hasRelatedWork W2072289276 @default.
• W2912643970 hasRelatedWork W2093835284 @default.
• W2912643970 hasRelatedWork W2511171894 @default.

• next