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- W2912645060 endingPage "7548" @default.
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- W2912645060 abstract "Significance Plant bioengineering will be necessary to sustain plant biology and agriculture, where the delivery of biomolecules such as DNA, RNA, or proteins to plant cells is at the crux of plant biotechnology. Here, we show that DNA nanostructures can internalize into plant cells and deliver siRNA to mature plant tissues without external aid. Furthermore, we demonstrate that nanostructure size, shape, compactness, and stiffness affect both nanostructure internalization into plant cells and subsequent gene silencing efficiency. Interestingly, we also find that the siRNA attachment locus affects the endogenous plant gene silencing pathway. Our work demonstrates programmable delivery of biomolecules to plants and details the figures of merit for future implementation of DNA nanostructures in agriculture." @default.
- W2912645060 created "2019-02-21" @default.
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- W2912645060 date "2019-03-25" @default.
- W2912645060 modified "2023-10-16" @default.
- W2912645060 title "DNA nanostructures coordinate gene silencing in mature plants" @default.
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- W2912645060 doi "https://doi.org/10.1073/pnas.1818290116" @default.
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