Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912647620> ?p ?o ?g. }
- W2912647620 endingPage "130" @default.
- W2912647620 startingPage "130" @default.
- W2912647620 abstract "Background: Retroelements (REs) are transposable elements occupying ~40% of the human genome that can regulate genes by providing transcription factor binding sites (TFBS). RE-linked TFBS profile can serve as a marker of gene transcriptional regulation evolution. This approach allows for interrogating the regulatory evolution of organisms with RE-rich genomes. We aimed to characterize the evolution of transcriptional regulation for human genes and molecular pathways using RE-linked TFBS accumulation as a metric. Methods: We characterized human genes and molecular pathways either enriched or deficient in RE-linked TFBS regulation. We used ENCODE database with mapped TFBS for 563 transcription factors in 13 human cell lines. For 24,389 genes and 3124 molecular pathways, we calculated the score of RE-linked TFBS regulation reflecting the regulatory evolution rate at the level of individual genes and molecular pathways. Results: The major groups enriched by RE regulation deal with gene regulation by microRNAs, olfaction, color vision, fertilization, cellular immune response, and amino acids and fatty acids metabolism and detoxication. The deficient groups were involved in translation, RNA transcription and processing, chromatin organization, and molecular signaling. Conclusion: We identified genes and molecular processes that have characteristics of especially high or low evolutionary rates at the level of RE-linked TFBS regulation in human lineage." @default.
- W2912647620 created "2019-02-21" @default.
- W2912647620 creator A5005133104 @default.
- W2912647620 creator A5008472454 @default.
- W2912647620 creator A5030144117 @default.
- W2912647620 creator A5038935137 @default.
- W2912647620 creator A5040729841 @default.
- W2912647620 creator A5045934950 @default.
- W2912647620 creator A5050321712 @default.
- W2912647620 creator A5064476651 @default.
- W2912647620 creator A5073346552 @default.
- W2912647620 creator A5077749610 @default.
- W2912647620 date "2019-02-06" @default.
- W2912647620 modified "2023-10-16" @default.
- W2912647620 title "Retroelement—Linked Transcription Factor Binding Patterns Point to Quickly Developing Molecular Pathways in Human Evolution" @default.
- W2912647620 cites W1543402161 @default.
- W2912647620 cites W1824413195 @default.
- W2912647620 cites W1883695122 @default.
- W2912647620 cites W1920348529 @default.
- W2912647620 cites W1971456303 @default.
- W2912647620 cites W1974330670 @default.
- W2912647620 cites W1982602899 @default.
- W2912647620 cites W1988847872 @default.
- W2912647620 cites W1993616000 @default.
- W2912647620 cites W1997758697 @default.
- W2912647620 cites W1999218372 @default.
- W2912647620 cites W2001389054 @default.
- W2912647620 cites W2001671544 @default.
- W2912647620 cites W2005188205 @default.
- W2912647620 cites W2020971598 @default.
- W2912647620 cites W2027108048 @default.
- W2912647620 cites W2037108634 @default.
- W2912647620 cites W2038584294 @default.
- W2912647620 cites W2038963685 @default.
- W2912647620 cites W2042086471 @default.
- W2912647620 cites W2051541780 @default.
- W2912647620 cites W2057514567 @default.
- W2912647620 cites W2064629259 @default.
- W2912647620 cites W2072713591 @default.
- W2912647620 cites W2093025275 @default.
- W2912647620 cites W2093026071 @default.
- W2912647620 cites W2101190060 @default.
- W2912647620 cites W2103017472 @default.
- W2912647620 cites W2110662009 @default.
- W2912647620 cites W2124073557 @default.
- W2912647620 cites W2129795133 @default.
- W2912647620 cites W2133465414 @default.
- W2912647620 cites W2133931128 @default.
- W2912647620 cites W2139367243 @default.
- W2912647620 cites W2143135390 @default.
- W2912647620 cites W2144605452 @default.
- W2912647620 cites W2151360491 @default.
- W2912647620 cites W2158217645 @default.
- W2912647620 cites W2168488626 @default.
- W2912647620 cites W2168909179 @default.
- W2912647620 cites W2171707557 @default.
- W2912647620 cites W2231865019 @default.
- W2912647620 cites W2259938310 @default.
- W2912647620 cites W2290849670 @default.
- W2912647620 cites W2330998918 @default.
- W2912647620 cites W2474005310 @default.
- W2912647620 cites W2529873061 @default.
- W2912647620 cites W2551839783 @default.
- W2912647620 cites W2604808360 @default.
- W2912647620 cites W2623897056 @default.
- W2912647620 cites W2737372261 @default.
- W2912647620 cites W2746202087 @default.
- W2912647620 cites W2746728221 @default.
- W2912647620 cites W2792928348 @default.
- W2912647620 cites W2950788368 @default.
- W2912647620 cites W4242002767 @default.
- W2912647620 doi "https://doi.org/10.3390/cells8020130" @default.
- W2912647620 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6406739" @default.
- W2912647620 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30736359" @default.
- W2912647620 hasPublicationYear "2019" @default.
- W2912647620 type Work @default.
- W2912647620 sameAs 2912647620 @default.
- W2912647620 citedByCount "11" @default.
- W2912647620 countsByYear W29126476202019 @default.
- W2912647620 countsByYear W29126476202020 @default.
- W2912647620 countsByYear W29126476202021 @default.
- W2912647620 countsByYear W29126476202023 @default.
- W2912647620 crossrefType "journal-article" @default.
- W2912647620 hasAuthorship W2912647620A5005133104 @default.
- W2912647620 hasAuthorship W2912647620A5008472454 @default.
- W2912647620 hasAuthorship W2912647620A5030144117 @default.
- W2912647620 hasAuthorship W2912647620A5038935137 @default.
- W2912647620 hasAuthorship W2912647620A5040729841 @default.
- W2912647620 hasAuthorship W2912647620A5045934950 @default.
- W2912647620 hasAuthorship W2912647620A5050321712 @default.
- W2912647620 hasAuthorship W2912647620A5064476651 @default.
- W2912647620 hasAuthorship W2912647620A5073346552 @default.
- W2912647620 hasAuthorship W2912647620A5077749610 @default.
- W2912647620 hasBestOaLocation W29126476201 @default.
- W2912647620 hasConcept C101762097 @default.
- W2912647620 hasConcept C104317684 @default.
- W2912647620 hasConcept C141231307 @default.
- W2912647620 hasConcept C150194340 @default.