Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912648242> ?p ?o ?g. }
- W2912648242 endingPage "52" @default.
- W2912648242 startingPage "46" @default.
- W2912648242 abstract "In the 1930s the progestin hormone produced by the corpus luteum was isolated and found to be a Δ4-keto-steroid. It was aptly named progesterone (P4) and in the following 30 years the capacity of P4 and derivatives to prevent preterm birth (PTB) was examined. Outcomes of multiple small studies suggested that progestin prophylaxis beginning at mid-gestation decreases the risk for PTB. Subsequent larger trials found that prophylaxis with weekly intramuscular injections of 17α-hydroxyprogesterone caproate (17HPC) beginning at mid-gestation decreased PTB risk in women with a history of PTB. Other trials found that daily vaginal P4 prophylaxis, also beginning at mid-gestation decreased PTB risk in women with a short cervix. Currently, prophylaxis with 17HPC (in women with a history of PTB) or vaginal P4 (in women with a short cervix) are used to prevent PTB. Recent advances in understanding the molecular biology of P4 signaling in uterine cells is revealing novel progestin-based targets for PTB prevention. One possibility is to use selective P4 receptor (PR) modulators (SPRMs) to boost PR anti-inflammatory activity that blocks labor, while simultaneously preventing PR phosphorylation that causes loss of P4/PR anti-inflammatory activity. This may be achieved by SPRMs that induce a specific PR conformation that prevents site-specific serine phosphorylation that inhibits anti-inflammatory activity. Further advances in understanding how P4 promotes uterine quiescence and how its labor blocking actions are withdrawn to trigger parturition will reveal novel therapeutic targets to more effectively prevent PTB." @default.
- W2912648242 created "2019-02-21" @default.
- W2912648242 creator A5013513758 @default.
- W2912648242 creator A5025805823 @default.
- W2912648242 creator A5029966761 @default.
- W2912648242 creator A5038424461 @default.
- W2912648242 creator A5039530529 @default.
- W2912648242 creator A5084239794 @default.
- W2912648242 date "2019-04-01" @default.
- W2912648242 modified "2023-10-06" @default.
- W2912648242 title "Progestin therapy to prevent preterm birth: History and effectiveness of current strategies and development of novel approaches" @default.
- W2912648242 cites W1515490616 @default.
- W2912648242 cites W151949596 @default.
- W2912648242 cites W1569017728 @default.
- W2912648242 cites W1668732801 @default.
- W2912648242 cites W1797680679 @default.
- W2912648242 cites W1798316307 @default.
- W2912648242 cites W1872593035 @default.
- W2912648242 cites W1902039366 @default.
- W2912648242 cites W1963928942 @default.
- W2912648242 cites W1966726213 @default.
- W2912648242 cites W1970078194 @default.
- W2912648242 cites W1971649468 @default.
- W2912648242 cites W1975755498 @default.
- W2912648242 cites W1982941640 @default.
- W2912648242 cites W1985649716 @default.
- W2912648242 cites W1985851148 @default.
- W2912648242 cites W1990466528 @default.
- W2912648242 cites W1992634340 @default.
- W2912648242 cites W1993160348 @default.
- W2912648242 cites W1995149397 @default.
- W2912648242 cites W1996061414 @default.
- W2912648242 cites W1996627248 @default.
- W2912648242 cites W1999217201 @default.
- W2912648242 cites W2003105309 @default.
- W2912648242 cites W2004773057 @default.
- W2912648242 cites W2005932095 @default.
- W2912648242 cites W2011025558 @default.
- W2912648242 cites W2012963127 @default.
- W2912648242 cites W2014424488 @default.
- W2912648242 cites W2015279480 @default.
- W2912648242 cites W2025995094 @default.
- W2912648242 cites W2027588860 @default.
- W2912648242 cites W2030147852 @default.
- W2912648242 cites W2039416528 @default.
- W2912648242 cites W2040424925 @default.
- W2912648242 cites W2044850116 @default.
- W2912648242 cites W2046141468 @default.
- W2912648242 cites W2046985268 @default.
- W2912648242 cites W2047299257 @default.
- W2912648242 cites W2048345592 @default.
- W2912648242 cites W2049511993 @default.
- W2912648242 cites W2049525497 @default.
- W2912648242 cites W2055316985 @default.
- W2912648242 cites W2058062168 @default.
- W2912648242 cites W2060010595 @default.
- W2912648242 cites W2062939456 @default.
- W2912648242 cites W2064727729 @default.
- W2912648242 cites W2065614074 @default.
- W2912648242 cites W2070309939 @default.
- W2912648242 cites W2074292009 @default.
- W2912648242 cites W2075719860 @default.
- W2912648242 cites W2078753269 @default.
- W2912648242 cites W2079693836 @default.
- W2912648242 cites W2082368668 @default.
- W2912648242 cites W2084663681 @default.
- W2912648242 cites W2087842862 @default.
- W2912648242 cites W2097110561 @default.
- W2912648242 cites W2100645707 @default.
- W2912648242 cites W2102823534 @default.
- W2912648242 cites W2103062385 @default.
- W2912648242 cites W2116382428 @default.
- W2912648242 cites W2122149074 @default.
- W2912648242 cites W2123518700 @default.
- W2912648242 cites W2124295934 @default.
- W2912648242 cites W2127227220 @default.
- W2912648242 cites W2131399370 @default.
- W2912648242 cites W2133270411 @default.
- W2912648242 cites W2136048424 @default.
- W2912648242 cites W2138053247 @default.
- W2912648242 cites W2143258863 @default.
- W2912648242 cites W2144088431 @default.
- W2912648242 cites W2144171496 @default.
- W2912648242 cites W2145385174 @default.
- W2912648242 cites W2150982004 @default.
- W2912648242 cites W2153258800 @default.
- W2912648242 cites W2166974958 @default.
- W2912648242 cites W2167644938 @default.
- W2912648242 cites W2170400471 @default.
- W2912648242 cites W2239068374 @default.
- W2912648242 cites W2247087212 @default.
- W2912648242 cites W2276408674 @default.
- W2912648242 cites W2340017361 @default.
- W2912648242 cites W2346735701 @default.
- W2912648242 cites W2398323469 @default.
- W2912648242 cites W2404904083 @default.
- W2912648242 cites W2405137614 @default.
- W2912648242 cites W2416738075 @default.