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- W2912648593 endingPage "495" @default.
- W2912648593 startingPage "457" @default.
- W2912648593 abstract "Exhausted CD8 T (Tex) cells are a distinct cell lineage that arise during chronic infections and cancers in animal models and humans. Tex cells are characterized by progressive loss of effector functions, high and sustained inhibitory receptor expression, metabolic dysregulation, poor memory recall and homeostatic self-renewal, and distinct transcriptional and epigenetic programs. The ability to reinvigorate Tex cells through inhibitory receptor blockade, such as αPD-1, highlights the therapeutic potential of targeting this population. Emerging insights into the mechanisms of exhaustion are informing immunotherapies for cancer and chronic infections. However, like other immune cells, Tex cells are heterogeneous and include progenitor and terminal subsets with unique characteristics and responses to checkpoint blockade. Here, we review our current understanding of Tex cell biology, including the developmental paths, transcriptional and epigenetic features, and cell intrinsic and extrinsic factors contributing to exhaustion and how this knowledge may inform therapeutic targeting of Tex cells in chronic infections, autoimmunity, and cancer." @default.
- W2912648593 created "2019-02-21" @default.
- W2912648593 creator A5009809063 @default.
- W2912648593 creator A5051377712 @default.
- W2912648593 creator A5057824723 @default.
- W2912648593 date "2019-04-26" @default.
- W2912648593 modified "2023-10-17" @default.
- W2912648593 title "CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer" @default.
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