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• W2912651726 endingPage "307" @default.
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• W2912651726 abstract "Emerging evidence suggests that endothelial-to-mesenchymal transition (EndMT) in endothelial dysfunction due to persistent inflammation is a key component and emerging concept in the pathogenesis of vascular diseases. Ginsenoside Rg3 (Rg3), an active compound from red ginseng, has been known to be important for vascular homeostasis. However, the effect of Rg3 on inflammation-induced EndMT has never been reported. Here, we hypothesize that Rg3 might reverse the inflammation-induced EndMT and serve as a novel therapeutic strategy for vascular diseases.EndMT was examined under an inflammatory condition mediated by the NOD1 agonist, γ-d-glutamyl-meso-diaminopimelic acid (iE-DAP), treatment in human umbilical vein endothelial cells. The expression of EndMT markers was determined by Western blot analysis, real-time polymerase chain reaction, and immunocytochemistry. The underlying mechanisms of Rg3-mediated EndMT regulation were investigated by modulating the microRNA expression.The NOD1 agonist, iE-DAP, led to a fibroblast-like morphology change with a decrease in the expression of endothelial markers and an increase in the expression of the mesenchymal marker, namely EndMT. On the other hand, Rg3 markedly attenuated the iE-DAP-induced EndMT and preserved the endothelial phenotype. Mechanically, miR-139 was downregulated in cells with iE-DAP-induced EndMT and partly reversed in response to Rg3 via the regulation of NF-κB signaling, suggesting that the Rg3-miR-139-5p-NF-κB axis is a key mediator in iE-DAP-induced EndMT.These results suggest, for the first time, that Rg3 can be used to inhibit inflammation-induced EndMT and may be a novel therapeutic option against EndMT-associated vascular diseases." @default.
• W2912651726 created "2019-02-21" @default.
• W2912651726 creator A5003130642 @default.
• W2912651726 creator A5064440520 @default.
• W2912651726 creator A5073581912 @default.
• W2912651726 creator A5086982270 @default.
• W2912651726 date "2020-03-01" @default.
• W2912651726 modified "2023-09-23" @default.
• W2912651726 title "Ginsenoside Rg3 protects against iE-DAP–induced endothelial-to-mesenchymal transition by regulating the miR-139-5p–NF-κB axis" @default.
• W2912651726 cites W1038470516 @default.
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• W2912651726 cites W1964962284 @default.
• W2912651726 cites W1979990833 @default.
• W2912651726 cites W1981348175 @default.
• W2912651726 cites W1987573944 @default.
• W2912651726 cites W1988915700 @default.
• W2912651726 cites W1994589643 @default.
• W2912651726 cites W1995089262 @default.
• W2912651726 cites W1999946358 @default.
• W2912651726 cites W2001166572 @default.
• W2912651726 cites W2002093513 @default.
• W2912651726 cites W2006176534 @default.
• W2912651726 cites W2006302849 @default.
• W2912651726 cites W2012768600 @default.
• W2912651726 cites W2015779295 @default.
• W2912651726 cites W2025054485 @default.
• W2912651726 cites W2025985350 @default.
• W2912651726 cites W2032813428 @default.
• W2912651726 cites W2038343314 @default.
• W2912651726 cites W2046401757 @default.
• W2912651726 cites W2050122576 @default.
• W2912651726 cites W2057007163 @default.
• W2912651726 cites W2059850288 @default.
• W2912651726 cites W2069294586 @default.
• W2912651726 cites W2077861814 @default.
• W2912651726 cites W2081186243 @default.
• W2912651726 cites W2083102682 @default.
• W2912651726 cites W2084571771 @default.
• W2912651726 cites W2085362771 @default.
• W2912651726 cites W2086758452 @default.
• W2912651726 cites W2089802936 @default.
• W2912651726 cites W2096335405 @default.
• W2912651726 cites W2097523448 @default.
• W2912651726 cites W2103328690 @default.
• W2912651726 cites W2111322736 @default.
• W2912651726 cites W2116878783 @default.
• W2912651726 cites W2120187885 @default.
• W2912651726 cites W2122044177 @default.
• W2912651726 cites W2180874464 @default.
• W2912651726 cites W2189543653 @default.
• W2912651726 cites W2267242658 @default.
• W2912651726 cites W2290846307 @default.
• W2912651726 cites W2331117946 @default.
• W2912651726 cites W2340834312 @default.
• W2912651726 cites W2409189950 @default.
• W2912651726 cites W2412360086 @default.
• W2912651726 cites W2518442429 @default.
• W2912651726 cites W2521020983 @default.
• W2912651726 cites W2523028783 @default.
• W2912651726 cites W2549187569 @default.
• W2912651726 cites W2553111862 @default.
• W2912651726 cites W2564001275 @default.
• W2912651726 cites W2564608154 @default.
• W2912651726 cites W2572946219 @default.
• W2912651726 cites W2577850075 @default.
• W2912651726 cites W2579890340 @default.
• W2912651726 cites W2618182495 @default.
• W2912651726 cites W2625477671 @default.
• W2912651726 cites W2745198396 @default.
• W2912651726 cites W2754689599 @default.
• W2912651726 cites W2756530545 @default.
• W2912651726 cites W2763296871 @default.
• W2912651726 cites W2772088068 @default.
• W2912651726 cites W2773138189 @default.
• W2912651726 cites W2789050487 @default.
• W2912651726 cites W2793024839 @default.
• W2912651726 cites W2793749910 @default.
• W2912651726 cites W2793949698 @default.
• W2912651726 cites W2795855957 @default.
• W2912651726 cites W60055417 @default.
• W2912651726 cites W794537917 @default.
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• W2912651726 doi "https://doi.org/10.1016/j.jgr.2019.01.003" @default.
• W2912651726 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7031736" @default.
• W2912651726 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32148412" @default.
• W2912651726 hasPublicationYear "2020" @default.
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• W2912651726 hasAuthorship W2912651726A5003130642 @default.
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