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• W2912654729 abstract "Introduction: Type 1 Autoimmune hepatitis constitutes more than 90 % cases of autoimmune hepatitis, is characterized by ANA and/or SMA positivity detected by operator dependent indirect immunofluoroscence. No single AIH-1 specific nuclear antigen has been identified, with ANA directed against chromatin, single or double stranded DNA, tRNA, SSA-Ro, snRNPs, ribososmal P protein, cyclic A or histones. No single pattern at present, characteristic of AIH. The aim of the current study was to exploit the database in Indian setting to determine nuclear antigens as targets for antinuclear antibodies in patients of autoimmune hepatitis type 1 using immunoblots to overcome operator dependence in diagnosis of autoimmune hepatitis. The study was done at Institute of Liver and Biliary Sciences, New Delhi, India, tertiary care center for liver disorders. Methods: 75 patients, >18 years who were antinuclear antibody positive with indirect immunofluorescence titre>=1:80, ALT >40 U/L, serum IgG(>16g/L), nonreactive viral hepatitis markers and within normal metabolic parameters were evaluated with immunoblots coated with nRNP/Sm, Sm, SS-A( SSAnative and Ro-52), SS-B, Scl-70, PM-Scl, Jo-1, CENP B, PCNA, dsDNA, Nucleosome, Histones, ribosomal P protein, AMA-M2, Sp100, LKM1, gp210, LC1 and SLA antigens Results: Antibodies to Ro-52 were present in 35 of 75 ANA+ sera(17+ alone, 18with SS-A). Antibodies to histones positive in 8 of 75 ANA + sera(4 histones +alone, 4+with antibodies to nRNP, SS-A, Ro-52, nucleosome). Antibodies to nucleosome were present in 8 of 75 sera(4 alone, 4 with antibodies to nRNP, SS-A, Ro-52, histones) Antibodies to n RNP were detected with other antibodies in 3 of 75 sera. Antibodies to centromere (Cenp-b) were found alone in 3 of 75 sera. Antibodies to PCNA were detected with anti SS-A in 4 of 75 sera. Antibodies to ds-DNA, Sm, Scl-70, PM-Scl, Jo-1 AMA-M2, ribososomal P-protein, Sp100, LKM-1, gp-120, LC1, and SLA were not detected in any of the 75 AIH patients' sera. 14 sera were non reactive to immunoblot. Conclusion: Immunoblots with antigens Ro52, SSA, PCNA, nRNP, histones and nucleosome, in Indian setting, can detect antibodies in majority of cases ruling out detection by immunofloroscence microscopy, which is highly subjective and also with no established criteria of ANA titres particularly in autoimmune hepatitis patients." @default.
• W2912654729 created "2019-02-21" @default.
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• W2912654729 date "2017-10-01" @default.
• W2912654729 modified "2023-09-27" @default.
• W2912654729 title "Antigen Determination in Autoimmune Hepatitis Type 1, Diagnosis Without Microscopy" @default.
• W2912654729 doi "https://doi.org/10.14309/00000434-201710001-00974" @default.
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