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- W2912656839 abstract "Introduction: We have continued to advocate the ischemic colitis could be caused by gut viral infection. This time, we have obtained not only clinical epidemiological results but experimental background (intracolonic pressure measurement) to alternative pathway of ischemic colitis pathophysiology, Methods: Ten normal subjects were studied. A colonoscope equipped with a manometry device was set at the sigmoid colon. Sigmoidoscopic appearance changes corresponding to intraluminal pressure was analyzed. Each mucosal picture was processed by image scanning device. By this device, we could obtain significant differences in redness of the mucosa as an index of hemoglobin (IHB) and get the change of mucosal blood supply. Intraluminal pressure is controlled using air insufflation apparatus with the range of 0-41mmHg. IHB (32XLog[R/G]) and intraluminal pressure were recorded at the same time. Results: IHG changed correlating to intraluminal pressure in 8 out of 10 patients with correlation coefficient (-0.875˜0.409), This IHG change means mucosal blood flow can be disturbed easily by intraluminal pressure increase. This change was confirmed in the case of Valsalva maneuver. Conclusion: We confirmed the mucosal blood supply can be changed according to intraluminal pressure increase. Our argument “ischemic colitis can be caused by simple viral infection of the intestine” is strongly supported." @default.
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- W2912656839 date "2017-10-01" @default.
- W2912656839 modified "2023-10-16" @default.
- W2912656839 title "Alternative Pathway to Ischemic Colitis Caused by Viral Gut Infection Have Gotten Theoretical Endorsement by Human Colon Manometry" @default.
- W2912656839 doi "https://doi.org/10.14309/00000434-201710001-02676" @default.
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