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• W2912657973 endingPage "4025" @default.
• W2912657973 startingPage "4011" @default.
• W2912657973 abstract "Transcription-coupled nucleotide excision repair (TC-NER) is a dedicated DNA repair pathway that removes transcription-blocking DNA lesions (TBLs). TC-NER is initiated by the recognition of lesion-stalled RNA Polymerase II by the joint action of the TC-NER factors Cockayne Syndrome protein A (CSA), Cockayne Syndrome protein B (CSB) and UV-Stimulated Scaffold Protein A (UVSSA). However, the exact recruitment mechanism of these factors toward TBLs remains elusive. Here, we study the recruitment mechanism of UVSSA using live-cell imaging and show that UVSSA accumulates at TBLs independent of CSA and CSB. Furthermore, using UVSSA deletion mutants, we could separate the CSA interaction function of UVSSA from its DNA damage recruitment activity, which is mediated by the UVSSA VHS and DUF2043 domains, respectively. Quantitative interaction proteomics showed that the Spt16 subunit of the histone chaperone FACT interacts with UVSSA, which is mediated by the DUF2043 domain. Spt16 is recruited to TBLs, independently of UVSSA, to stimulate UVSSA recruitment and TC-NER-mediated repair. Spt16 specifically affects UVSSA, as Spt16 depletion did not affect CSB recruitment, highlighting that different chromatin-modulating factors regulate different reaction steps of the highly orchestrated TC-NER pathway." @default.
• W2912657973 created "2019-02-21" @default.
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• W2912657973 date "2019-02-04" @default.
• W2912657973 modified "2023-10-16" @default.
• W2912657973 title "FACT subunit Spt16 controls UVSSA recruitment to lesion-stalled RNA Pol II and stimulates TC-NER" @default.
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• W2912657973 cites W1977982042 @default.
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• W2912657973 doi "https://doi.org/10.1093/nar/gkz055" @default.
• W2912657973 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6486547" @default.
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• W2912657973 hasPublicationYear "2019" @default.
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