FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912661332> ?p ?o ?g. }

• W2912661332 abstract "Abstract Accumulating evidence suggests that microRNAs and DNA methylation can cause tumor suppressor gene inactivation and promote tumor malignancy. However, the functional mechanisms of miR-29c-3p and DNA methylation in hepatocellular carcinoma (HCC) are unclear. Here, we reported that miR-29c-3p expression was significantly downregulated in HCC tissues and cell lines. Low miR-29c-3p expression correlated with tumor size, multiplicity pathologic features, and shorter overall survival. Overexpression of miR-29c-3p significantly inhibited HCC cell proliferation, apoptosis, migration, and tumor growth in vivo. Moreover, DNA methyltransferases 3B (DNMT3B) was upregulated in HCC tissues, and was negatively correlated with miR-29c-3p expression. Luciferase reporter and western blotting assays revealed that DNMT3B is a target gene directly regulated by miR-29c-3p. Furthermore, miR-29c-3p regulates the methylation of large tumor suppressor gene 1 (LATS1) by DNMT3B, and abnormal methylation of LATS1 inactivates Hippo signaling pathway. We subsequently identified that high DNMT3B expression and low LATS1 expression were frequently identified in HCC tissues and were associated with poor prognosis. In conclusion, our results indicate that miR-29c-3p acts as a tumor suppressor in HCC by targeting DNMT3B and the LATS1-associated Hippo signaling pathway, which might represent a novel potential therapeutic target for HCC." @default.
• W2912661332 created "2019-02-21" @default.
• W2912661332 creator A5014175303 @default.
• W2912661332 creator A5021246987 @default.
• W2912661332 creator A5032624863 @default.
• W2912661332 creator A5036176693 @default.
• W2912661332 creator A5047750313 @default.
• W2912661332 creator A5075676648 @default.
• W2912661332 creator A5076730307 @default.
• W2912661332 creator A5083787337 @default.
• W2912661332 date "2019-01-18" @default.
• W2912661332 modified "2023-10-11" @default.
• W2912661332 title "miR-29c-3p regulates DNMT3B and LATS1 methylation to inhibit tumor progression in hepatocellular carcinoma" @default.
• W2912661332 cites W1975338049 @default.
• W2912661332 cites W1989827688 @default.
• W2912661332 cites W2000225283 @default.
• W2912661332 cites W2017408113 @default.
• W2912661332 cites W2018333960 @default.
• W2912661332 cites W2030712838 @default.
• W2912661332 cites W2036516235 @default.
• W2912661332 cites W2036848594 @default.
• W2912661332 cites W2055986128 @default.
• W2912661332 cites W2059981122 @default.
• W2912661332 cites W2060446375 @default.
• W2912661332 cites W2074849180 @default.
• W2912661332 cites W2102724983 @default.
• W2912661332 cites W2103177465 @default.
• W2912661332 cites W2108203277 @default.
• W2912661332 cites W2112933956 @default.
• W2912661332 cites W2131065995 @default.
• W2912661332 cites W2142792857 @default.
• W2912661332 cites W2146131918 @default.
• W2912661332 cites W2148056172 @default.
• W2912661332 cites W2149816812 @default.
• W2912661332 cites W2152725087 @default.
• W2912661332 cites W2161737824 @default.
• W2912661332 cites W2162674813 @default.
• W2912661332 cites W2171141151 @default.
• W2912661332 cites W2223413920 @default.
• W2912661332 cites W2272984102 @default.
• W2912661332 cites W2279047507 @default.
• W2912661332 cites W2532586679 @default.
• W2912661332 cites W2557658326 @default.
• W2912661332 cites W2570618306 @default.
• W2912661332 cites W2592254638 @default.
• W2912661332 cites W2593320405 @default.
• W2912661332 cites W2594781652 @default.
• W2912661332 doi "https://doi.org/10.1038/s41419-018-1281-7" @default.
• W2912661332 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6362005" @default.
• W2912661332 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30718452" @default.
• W2912661332 hasPublicationYear "2019" @default.
• W2912661332 type Work @default.
• W2912661332 sameAs 2912661332 @default.
• W2912661332 citedByCount "69" @default.
• W2912661332 countsByYear W29126613322019 @default.
• W2912661332 countsByYear W29126613322020 @default.
• W2912661332 countsByYear W29126613322021 @default.
• W2912661332 countsByYear W29126613322022 @default.
• W2912661332 countsByYear W29126613322023 @default.
• W2912661332 crossrefType "journal-article" @default.
• W2912661332 hasAuthorship W2912661332A5014175303 @default.
• W2912661332 hasAuthorship W2912661332A5021246987 @default.
• W2912661332 hasAuthorship W2912661332A5032624863 @default.
• W2912661332 hasAuthorship W2912661332A5036176693 @default.
• W2912661332 hasAuthorship W2912661332A5047750313 @default.
• W2912661332 hasAuthorship W2912661332A5075676648 @default.
• W2912661332 hasAuthorship W2912661332A5076730307 @default.
• W2912661332 hasAuthorship W2912661332A5083787337 @default.
• W2912661332 hasBestOaLocation W29126613321 @default.
• W2912661332 hasConcept C104317684 @default.
• W2912661332 hasConcept C121608353 @default.
• W2912661332 hasConcept C145059251 @default.
• W2912661332 hasConcept C150194340 @default.
• W2912661332 hasConcept C153911025 @default.
• W2912661332 hasConcept C172512520 @default.
• W2912661332 hasConcept C190727270 @default.
• W2912661332 hasConcept C2777142704 @default.
• W2912661332 hasConcept C2778264664 @default.
• W2912661332 hasConcept C33288867 @default.
• W2912661332 hasConcept C502942594 @default.
• W2912661332 hasConcept C54355233 @default.
• W2912661332 hasConcept C555283112 @default.
• W2912661332 hasConcept C62112901 @default.
• W2912661332 hasConcept C86803240 @default.
• W2912661332 hasConcept C91965660 @default.
• W2912661332 hasConceptScore W2912661332C104317684 @default.
• W2912661332 hasConceptScore W2912661332C121608353 @default.
• W2912661332 hasConceptScore W2912661332C145059251 @default.
• W2912661332 hasConceptScore W2912661332C150194340 @default.
• W2912661332 hasConceptScore W2912661332C153911025 @default.
• W2912661332 hasConceptScore W2912661332C172512520 @default.
• W2912661332 hasConceptScore W2912661332C190727270 @default.
• W2912661332 hasConceptScore W2912661332C2777142704 @default.
• W2912661332 hasConceptScore W2912661332C2778264664 @default.
• W2912661332 hasConceptScore W2912661332C33288867 @default.
• W2912661332 hasConceptScore W2912661332C502942594 @default.
• W2912661332 hasConceptScore W2912661332C54355233 @default.
• W2912661332 hasConceptScore W2912661332C555283112 @default.
• W2912661332 hasConceptScore W2912661332C62112901 @default.
• W2912661332 hasConceptScore W2912661332C86803240 @default.

• next