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- W2912662493 abstract "In Parkinson’s disease, the degeneration of the midbrain dopaminergic neurons is consistently associated with modified metabolic activity in the cerebellum. Here we examined the functional reorganization taking place in the cerebello–cerebral circuit in a murine model of Parkinson’s disease with 6-OHDA lesion of midbrain dopaminergic neurons. Cerebellar optogenetic stimulations evoked similar movements in control and lesioned mice, suggesting a normal coupling of cerebellum to the motor effectors after the lesion. In freely moving animals, the firing rate in the primary motor cortex was decreased after the lesion, while cerebellar nuclei neurons showed an increased firing rate. This increase may result from reduced inhibitory Purkinje cells inputs, since a population of slow and irregular Purkinje cells was observed in the cerebellar hemispheres of lesioned animals. Moreover, cerebellar stimulations generated smaller electrocortical responses in the motor cortex of lesioned animals suggesting a weaker cerebello–cerebral coupling. Overall these results indicate the presence of functional changes in the cerebello–cerebral circuit, but their ability to correct cortical dysfunction may be limited due to functional uncoupling between the cerebellum and cerebral cortex." @default.
- W2912662493 created "2019-02-21" @default.
- W2912662493 creator A5027771259 @default.
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- W2912662493 creator A5056969405 @default.
- W2912662493 creator A5082131773 @default.
- W2912662493 creator A5086297495 @default.
- W2912662493 date "2019-01-31" @default.
- W2912662493 modified "2023-10-09" @default.
- W2912662493 title "Functional Alteration of Cerebello–Cerebral Coupling in an Experimental Mouse Model of Parkinson’s Disease" @default.
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