FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912662937> ?p ?o ?g. }

• W2912662937 abstract "Abstract UVR8 (UV RESISTANCE LOCUS 8) is a UV-B photoreceptor responsible for initiating UV-B signalling in plants. UVR8 is a homodimer in its signalling inactive form. Upon absorption of UV radiation, the protein monomerizes into its photoactivated state. In the monomeric form, UVR8 binds the E3 ubiquitin ligase COP1 (CONSTITUTIVELY PHOTOMORPHOGENIC 1), triggering subsequent UV-B-dependent photomorphogenic development in plants. Recent in vivo experiments have shown that the UVR8 C-terminal region (aa 397–423; UVR8 C27 ) alone is sufficient to regulate the activity of COP1. In this work, CD spectroscopy and NMR experiments showed that the UVR8 C27 domain was non-structured but gained secondary structure at higher temperatures leading to increased order. Bias-exchange metadynamics simulations were also performed to evaluate the free energy landscape of UVR8 C27 . An inverted free energy landscape was revealed, with a disordered structure in the global energy minimum. Flanking the global energy minimum, more structured states were found at higher energies. Furthermore, stabilization of the low energy disordered state was attributed to a proline residue, P411, as evident from P411A mutant data. P411 is also a key residue in UVR8 binding to COP1. UVR8 C27 is therefore structurally competent to function as a molecular switch for interaction of UVR8 with different binding partners since at higher free energies different structural conformations are being induced in this peptide. P411 has a key role for this function." @default.
• W2912662937 created "2019-02-21" @default.
• W2912662937 creator A5001315059 @default.
• W2912662937 creator A5040529135 @default.
• W2912662937 creator A5065532211 @default.
• W2912662937 creator A5072606310 @default.
• W2912662937 date "2019-01-28" @default.
• W2912662937 modified "2023-10-16" @default.
• W2912662937 title "Proline 411 biases the conformation of the intrinsically disordered plant UVR8 photoreceptor C27 domain altering the functional properties of the peptide" @default.
• W2912662937 cites W1501347866 @default.
• W2912662937 cites W1608084603 @default.
• W2912662937 cites W1883224873 @default.
• W2912662937 cites W1964686357 @default.
• W2912662937 cites W1971706091 @default.
• W2912662937 cites W1976499671 @default.
• W2912662937 cites W1986583145 @default.
• W2912662937 cites W1986986500 @default.
• W2912662937 cites W1989270637 @default.
• W2912662937 cites W1991794210 @default.
• W2912662937 cites W1997828001 @default.
• W2912662937 cites W1998587460 @default.
• W2912662937 cites W2008693552 @default.
• W2912662937 cites W2009613200 @default.
• W2912662937 cites W2026727321 @default.
• W2912662937 cites W2030138948 @default.
• W2912662937 cites W2035687084 @default.
• W2912662937 cites W2036271007 @default.
• W2912662937 cites W2041638382 @default.
• W2912662937 cites W2052242630 @default.
• W2912662937 cites W2057022710 @default.
• W2912662937 cites W2059013803 @default.
• W2912662937 cites W2065919348 @default.
• W2912662937 cites W2068778916 @default.
• W2912662937 cites W2073623394 @default.
• W2912662937 cites W2092785935 @default.
• W2912662937 cites W2097903157 @default.
• W2912662937 cites W2100744249 @default.
• W2912662937 cites W2100951456 @default.
• W2912662937 cites W2115431543 @default.
• W2912662937 cites W2126103104 @default.
• W2912662937 cites W2127005921 @default.
• W2912662937 cites W2130359603 @default.
• W2912662937 cites W2131774142 @default.
• W2912662937 cites W2133721361 @default.
• W2912662937 cites W2134661315 @default.
• W2912662937 cites W2135959854 @default.
• W2912662937 cites W2138805658 @default.
• W2912662937 cites W2148019935 @default.
• W2912662937 cites W2149655632 @default.
• W2912662937 cites W2159271186 @default.
• W2912662937 cites W2160591382 @default.
• W2912662937 cites W2165402269 @default.
• W2912662937 cites W2169821755 @default.
• W2912662937 cites W2171268876 @default.
• W2912662937 cites W2238155968 @default.
• W2912662937 cites W2314126407 @default.
• W2912662937 cites W2316383613 @default.
• W2912662937 cites W2462984106 @default.
• W2912662937 cites W2785336306 @default.
• W2912662937 cites W2790632663 @default.
• W2912662937 cites W2897132891 @default.
• W2912662937 doi "https://doi.org/10.1038/s41598-018-37005-8" @default.
• W2912662937 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6349876" @default.
• W2912662937 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30692548" @default.
• W2912662937 hasPublicationYear "2019" @default.
• W2912662937 type Work @default.
• W2912662937 sameAs 2912662937 @default.
• W2912662937 citedByCount "5" @default.
• W2912662937 countsByYear W29126629372019 @default.
• W2912662937 countsByYear W29126629372020 @default.
• W2912662937 countsByYear W29126629372021 @default.
• W2912662937 countsByYear W29126629372023 @default.
• W2912662937 crossrefType "journal-article" @default.
• W2912662937 hasAuthorship W2912662937A5001315059 @default.
• W2912662937 hasAuthorship W2912662937A5040529135 @default.
• W2912662937 hasAuthorship W2912662937A5065532211 @default.
• W2912662937 hasAuthorship W2912662937A5072606310 @default.
• W2912662937 hasBestOaLocation W29126629371 @default.
• W2912662937 hasConcept C104317684 @default.
• W2912662937 hasConcept C119621388 @default.
• W2912662937 hasConcept C12554922 @default.
• W2912662937 hasConcept C134459356 @default.
• W2912662937 hasConcept C143065580 @default.
• W2912662937 hasConcept C147597530 @default.
• W2912662937 hasConcept C185592680 @default.
• W2912662937 hasConcept C25602115 @default.
• W2912662937 hasConcept C2779281246 @default.
• W2912662937 hasConcept C2779815552 @default.
• W2912662937 hasConcept C515207424 @default.
• W2912662937 hasConcept C55493867 @default.
• W2912662937 hasConcept C59593255 @default.
• W2912662937 hasConcept C62752575 @default.
• W2912662937 hasConcept C86803240 @default.
• W2912662937 hasConcept C95444343 @default.
• W2912662937 hasConceptScore W2912662937C104317684 @default.
• W2912662937 hasConceptScore W2912662937C119621388 @default.
• W2912662937 hasConceptScore W2912662937C12554922 @default.
• W2912662937 hasConceptScore W2912662937C134459356 @default.
• W2912662937 hasConceptScore W2912662937C143065580 @default.
• W2912662937 hasConceptScore W2912662937C147597530 @default.

• next