Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912666599> ?p ?o ?g. }
- W2912666599 endingPage "87" @default.
- W2912666599 startingPage "68" @default.
- W2912666599 abstract "β-Carotene intake and tissue/blood concentrations have been associated with reduced incidence of several chronic diseases. Further bioactive carotenoid-metabolites can modulate the expression of specific genes mainly via the nuclear hormone receptors: retinoic acid receptor- and retinoid X receptor-mediated signalling. To better understand the metabolic conversion of β-carotene, inter-individual differences regarding β-carotene bioavailability and bioactivity are key steps that determine its further metabolism and bioactivation and mediated signalling. Major carotenoid metabolites, the retinoids, can be stored as esters or further oxidised and excreted via phase 2 metabolism pathways. In this review, we aim to highlight the major critical control points that determine the fate of β-carotene in the human body, with a special emphasis on β-carotene oxygenase 1. The hypothesis that higher dietary β-carotene intake and serum level results in higher β-carotene-mediated signalling is partly questioned. Alternative autoregulatory mechanisms in β-carotene / retinoid-mediated signalling are highlighted to better predict and optimise nutritional strategies involving β-carotene-related health beneficial mediated effects." @default.
- W2912666599 created "2019-02-21" @default.
- W2912666599 creator A5009972485 @default.
- W2912666599 creator A5039971652 @default.
- W2912666599 creator A5045415268 @default.
- W2912666599 creator A5059364953 @default.
- W2912666599 creator A5081220483 @default.
- W2912666599 creator A5082279190 @default.
- W2912666599 creator A5085522545 @default.
- W2912666599 date "2019-02-01" @default.
- W2912666599 modified "2023-10-14" @default.
- W2912666599 title "β-Carotene in the human body: metabolic bioactivation pathways – from digestion to tissue distribution and excretion" @default.
- W2912666599 cites W1049636649 @default.
- W2912666599 cites W1481701184 @default.
- W2912666599 cites W1523820703 @default.
- W2912666599 cites W1525444530 @default.
- W2912666599 cites W1527521373 @default.
- W2912666599 cites W1533781040 @default.
- W2912666599 cites W1553693482 @default.
- W2912666599 cites W1591371645 @default.
- W2912666599 cites W1617088452 @default.
- W2912666599 cites W1654146805 @default.
- W2912666599 cites W1803030534 @default.
- W2912666599 cites W1855180909 @default.
- W2912666599 cites W1900037177 @default.
- W2912666599 cites W1902956277 @default.
- W2912666599 cites W1906287018 @default.
- W2912666599 cites W1912708285 @default.
- W2912666599 cites W1916110024 @default.
- W2912666599 cites W1918723691 @default.
- W2912666599 cites W1943794462 @default.
- W2912666599 cites W1944496442 @default.
- W2912666599 cites W1947092165 @default.
- W2912666599 cites W1953845743 @default.
- W2912666599 cites W1959459166 @default.
- W2912666599 cites W1966289046 @default.
- W2912666599 cites W1966361246 @default.
- W2912666599 cites W1968649812 @default.
- W2912666599 cites W1972047669 @default.
- W2912666599 cites W1972662713 @default.
- W2912666599 cites W1973865418 @default.
- W2912666599 cites W1974149430 @default.
- W2912666599 cites W1976521385 @default.
- W2912666599 cites W1977175493 @default.
- W2912666599 cites W1980511079 @default.
- W2912666599 cites W1980927809 @default.
- W2912666599 cites W1982925791 @default.
- W2912666599 cites W1984509210 @default.
- W2912666599 cites W1985413280 @default.
- W2912666599 cites W1986882894 @default.
- W2912666599 cites W1986962805 @default.
- W2912666599 cites W1988123744 @default.
- W2912666599 cites W1989658935 @default.
- W2912666599 cites W1991759259 @default.
- W2912666599 cites W1992438813 @default.
- W2912666599 cites W1995283755 @default.
- W2912666599 cites W1995399390 @default.
- W2912666599 cites W1996292767 @default.
- W2912666599 cites W1997826053 @default.
- W2912666599 cites W1999132350 @default.
- W2912666599 cites W1999669689 @default.
- W2912666599 cites W2001616502 @default.
- W2912666599 cites W2003067274 @default.
- W2912666599 cites W2003105484 @default.
- W2912666599 cites W2006992210 @default.
- W2912666599 cites W2007884452 @default.
- W2912666599 cites W2009053719 @default.
- W2912666599 cites W2010545962 @default.
- W2912666599 cites W2010786899 @default.
- W2912666599 cites W2012428888 @default.
- W2912666599 cites W2013390681 @default.
- W2912666599 cites W2013643227 @default.
- W2912666599 cites W2013651825 @default.
- W2912666599 cites W2015802676 @default.
- W2912666599 cites W2017293137 @default.
- W2912666599 cites W2017578370 @default.
- W2912666599 cites W2017651116 @default.
- W2912666599 cites W2018056417 @default.
- W2912666599 cites W2019631619 @default.
- W2912666599 cites W2019928465 @default.
- W2912666599 cites W2024135205 @default.
- W2912666599 cites W2024153033 @default.
- W2912666599 cites W2024610994 @default.
- W2912666599 cites W2026832748 @default.
- W2912666599 cites W2027451664 @default.
- W2912666599 cites W2027876857 @default.
- W2912666599 cites W2028626013 @default.
- W2912666599 cites W2029857489 @default.
- W2912666599 cites W2031637049 @default.
- W2912666599 cites W2031770400 @default.
- W2912666599 cites W2032502259 @default.
- W2912666599 cites W2032653735 @default.
- W2912666599 cites W2033937765 @default.
- W2912666599 cites W2037263538 @default.
- W2912666599 cites W2040639505 @default.
- W2912666599 cites W2041270901 @default.
- W2912666599 cites W2041767949 @default.
- W2912666599 cites W2042904359 @default.