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- W2912667912 abstract "Eosinophils have long been recognized as a central effector cell in the lungs of asthmatic patients. They contribute to airway inflammation and remodeling through releasing several molecules such as cytokines, granule proteins, lipid mediators and extracellular traps/vesicles. Repeated evidence reveals that intense eosinophil infiltration in upper and lower airway mucosae contributes to the pathogenesis of aspirin-exacerbated respiratory disease (AERD). Persistent eosinophilia is found to be associated with type 2 immune responses, cysteinyl leukotriene overproduction and eosinophil-epithelium interactions. This review highlights recent findings about key mechanisms of eosinophil activation in the airway inflammation of AERD. In addition, current biologics (targeting type 2 immune responses) were suggested to control eosinophilic inflammation for AERD patients." @default.
- W2912667912 created "2019-02-21" @default.
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- W2912667912 date "2019-01-01" @default.
- W2912667912 modified "2023-10-14" @default.
- W2912667912 title "Which Factors Associated With Activated Eosinophils Contribute to the Pathogenesis of Aspirin-Exacerbated Respiratory Disease?" @default.
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- W2912667912 doi "https://doi.org/10.4168/aair.2019.11.3.320" @default.
- W2912667912 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6439191" @default.
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