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- W2912668345 abstract "This gastrointestinal stromal tumor (GIST) involves the duodenal serosa and the mesenteric soft tissue.What is the most characteristic and common genetic abnormality found in gastrointestinal stromal tumors?a.Activating mutations in KITb.BRAF V600E mutationc.RET mutationd.Translocation involving ALK Answer: a. Activating mutations in KIT Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal (GI) tract. Approximately 80% of GISTs are associated with activating mutations of KIT. 1Charville G.W. Longacre T.A. Surgical pathology of gastrointestinal stromal tumors: practical implications of morphologic and molecular heterogeneity for precision medicine.Adv Anat Pathol. 2017; 24: 336-353Google Scholar This mutation is also an important therapeutic target. Platelet-derived growth factor receptor alpha (PDGRA) mutations are identified in approximately 5% of GIST.1Charville G.W. Longacre T.A. Surgical pathology of gastrointestinal stromal tumors: practical implications of morphologic and molecular heterogeneity for precision medicine.Adv Anat Pathol. 2017; 24: 336-353Google Scholar GIST may occur in a syndromic setting, characterized by succinate dehydrogenase (SDH) gene deficiency, which is mutually exclusive from KIT or PDGRA mutations. Immunostains for DOG1 and KIT are used in the diagnosis of these tumors." @default.
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- W2912668345 date "2019-02-01" @default.
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- W2912668345 title "Gastrointestinal Stromal Tumor" @default.
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- W2912668345 doi "https://doi.org/10.1016/j.mayocp.2018.12.019" @default.
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