Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912668636> ?p ?o ?g. }
- W2912668636 endingPage "1200" @default.
- W2912668636 startingPage "1187" @default.
- W2912668636 abstract "Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases, characterized by the accumulation of extracellular amyloid plaques and intraneuronal neurofibrillary tangles. These tangles mainly consist of hyperphosphorylated tau protein. As it induces tau hyperphosphorylation in vitro and in vivo, hypothermia is a useful tool for screening potential neuroprotective compounds that ameliorate tau pathology. In this study, we examined the effect of prolactin-releasing peptide (PrRP), its lipidized analog palm11-PrRP31 and glucagon-like-peptide-1 agonist liraglutide, substances with anorexigenic and antidiabetic properties, on tau phosphorylation and on the main kinases and phosphatases involved in AD development. Our study was conducted in a neuroblastoma cell line SH-SY5Y and rat primary neuronal cultures under normothermic and hypothermic conditions. Hypothermia induced a significant increase in tau phosphorylation at the pThr212 and pSer396/pSer404 epitopes. The palmitoylated analogs liraglutide and palm11-PrRP31 attenuated tau hyperphosphorylation, suggesting their potential use in the treatment of neurodegenerative diseases." @default.
- W2912668636 created "2019-02-21" @default.
- W2912668636 creator A5004679918 @default.
- W2912668636 creator A5007876269 @default.
- W2912668636 creator A5025818311 @default.
- W2912668636 creator A5025952250 @default.
- W2912668636 creator A5044469104 @default.
- W2912668636 creator A5057891901 @default.
- W2912668636 creator A5061571488 @default.
- W2912668636 date "2019-02-19" @default.
- W2912668636 modified "2023-10-05" @default.
- W2912668636 title "Lipidized Prolactin-Releasing Peptide Agonist Attenuates Hypothermia-Induced Tau Hyperphosphorylation in Neurons" @default.
- W2912668636 cites W1029387585 @default.
- W2912668636 cites W1502767139 @default.
- W2912668636 cites W1577837690 @default.
- W2912668636 cites W1589427638 @default.
- W2912668636 cites W1592633314 @default.
- W2912668636 cites W1600934558 @default.
- W2912668636 cites W1969417329 @default.
- W2912668636 cites W1969965994 @default.
- W2912668636 cites W1974374278 @default.
- W2912668636 cites W1980768099 @default.
- W2912668636 cites W1987093796 @default.
- W2912668636 cites W1990366009 @default.
- W2912668636 cites W2002706020 @default.
- W2912668636 cites W2005199015 @default.
- W2912668636 cites W2020053653 @default.
- W2912668636 cites W2022178426 @default.
- W2912668636 cites W2022614808 @default.
- W2912668636 cites W2022847635 @default.
- W2912668636 cites W2030270894 @default.
- W2912668636 cites W2032920422 @default.
- W2912668636 cites W2034800901 @default.
- W2912668636 cites W2035873080 @default.
- W2912668636 cites W2046892908 @default.
- W2912668636 cites W2048660711 @default.
- W2912668636 cites W2057160717 @default.
- W2912668636 cites W2064859339 @default.
- W2912668636 cites W2065851098 @default.
- W2912668636 cites W2073012903 @default.
- W2912668636 cites W2077859404 @default.
- W2912668636 cites W2078599058 @default.
- W2912668636 cites W2080700709 @default.
- W2912668636 cites W2099137703 @default.
- W2912668636 cites W2102711224 @default.
- W2912668636 cites W2106464041 @default.
- W2912668636 cites W2112694389 @default.
- W2912668636 cites W2126279450 @default.
- W2912668636 cites W2140461841 @default.
- W2912668636 cites W2143214705 @default.
- W2912668636 cites W2147091345 @default.
- W2912668636 cites W2170332763 @default.
- W2912668636 cites W2170725855 @default.
- W2912668636 cites W2216861141 @default.
- W2912668636 cites W2228086361 @default.
- W2912668636 cites W2324851902 @default.
- W2912668636 cites W2330887677 @default.
- W2912668636 cites W2530884864 @default.
- W2912668636 cites W2533142483 @default.
- W2912668636 cites W2548465653 @default.
- W2912668636 cites W2749266932 @default.
- W2912668636 cites W2784036837 @default.
- W2912668636 cites W2794763910 @default.
- W2912668636 cites W4211156109 @default.
- W2912668636 doi "https://doi.org/10.3233/jad-180837" @default.
- W2912668636 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30689580" @default.
- W2912668636 hasPublicationYear "2019" @default.
- W2912668636 type Work @default.
- W2912668636 sameAs 2912668636 @default.
- W2912668636 citedByCount "6" @default.
- W2912668636 countsByYear W29126686362019 @default.
- W2912668636 countsByYear W29126686362020 @default.
- W2912668636 countsByYear W29126686362021 @default.
- W2912668636 countsByYear W29126686362022 @default.
- W2912668636 countsByYear W29126686362023 @default.
- W2912668636 crossrefType "journal-article" @default.
- W2912668636 hasAuthorship W2912668636A5004679918 @default.
- W2912668636 hasAuthorship W2912668636A5007876269 @default.
- W2912668636 hasAuthorship W2912668636A5025818311 @default.
- W2912668636 hasAuthorship W2912668636A5025952250 @default.
- W2912668636 hasAuthorship W2912668636A5044469104 @default.
- W2912668636 hasAuthorship W2912668636A5057891901 @default.
- W2912668636 hasAuthorship W2912668636A5061571488 @default.
- W2912668636 hasConcept C11960822 @default.
- W2912668636 hasConcept C121738310 @default.
- W2912668636 hasConcept C126322002 @default.
- W2912668636 hasConcept C134018914 @default.
- W2912668636 hasConcept C169760540 @default.
- W2912668636 hasConcept C170493617 @default.
- W2912668636 hasConcept C178666793 @default.
- W2912668636 hasConcept C184235292 @default.
- W2912668636 hasConcept C185592680 @default.
- W2912668636 hasConcept C25498285 @default.
- W2912668636 hasConcept C2777390192 @default.
- W2912668636 hasConcept C2778198054 @default.
- W2912668636 hasConcept C2778670691 @default.
- W2912668636 hasConcept C2778938600 @default.
- W2912668636 hasConcept C2779134260 @default.