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• W2912669738 abstract "In patients with an acute coronary syndrome undergoing percutaneous coronary intervention, novel P2Y12 receptor inhibitors, prasugrel and ticagrelor, are proposed as first-line antiplatelet agents in the absence of contraindications and up to a year from the index event. However, de-escalation of treatment to clopidogrel occurs with a variable frequency in real-life practice, most commonly due to an increased bleeding potential, more frequent side effects, and a higher cost for the novel agents. Pharmacodynamic studies provide most of the data on guidance for de-escalation. Despite positive messages from recent trials and registries, lack of definitive efficacy or safety results of such a strategy remains an obstacle to suggest de-escalation in a routine basis. Carefully designed studies are likely to improve our understanding of the impact of de-escalation and help to better define its position in current pharmacotherapy." @default.
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• W2912669738 date "2019-02-05" @default.
• W2912669738 modified "2023-09-24" @default.
• W2912669738 title "De-Escalation of Treatment With Oral P2Y12 Receptor Inhibitors: Current Status and Perspectives" @default.
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• W2912669738 doi "https://doi.org/10.1177/1074248418823724" @default.
• W2912669738 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30722685" @default.
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