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W2912678344 abstract "Purpose: To evaluate the efficacy of two commonly employed treatments for Helicobacter pylori infection and the impact of bacterial resistance to antibiotics on eradication rate during a pharmacokinetic study of eradication therapy. Methods: Seventy-nine consecutive H. pylori-positive patients were randomly enrolled to receive a 10-day treatment with either lansoprazole 30 mg plus amoxicillin 1 g and clarithromycin 500 mg (all b.i.d., Group A, N = 40); or bismuth subcitrate 125 mg q.i.d. plus tetracycline 500 mg q.i.d and furazolidone 200 mg b.i.d. (Group B, N = 39). Patients took the first dose of the therapy on days 1, 5 and 10 under supervision at our facility. H. pylori status was reassessed at least 60 days following completion of the therapy and bacterial resistance to the antibiotics was investigated. Results: Four patients from group A and 2 patients from group B were lost to follow up. Both treatments resulted in similar H. pylori eradication rate: 82.5%–77% (per protocol), 80.5%–73% (intention-to-treat) in Group A and B, respectively (N.S.). Twelve patients in group A were resistant to clarithromycin and in one of them resistance to and amoxicillin was also present. In Group B there were only two patients with resistance to tetracycline. No resistance to furazolidone was detected. Pre-treatment resistance did not impact eradication rates for both groups. Conclusion: Primary resistance to clarithromycin or amoxicillin previously considered a potentially serious problem for the eradication of H. pylori infection may be not as important as other factors such as compliance for those patients using these drugs." @default.
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W2912678344 date "2007-09-01" @default.
W2912678344 modified "2023-09-28" @default.
W2912678344 title "Does Increased Primary Resistance to Recommended Antibiotics Really Affect Helicobacter pylori Eradication?" @default.
W2912678344 doi "https://doi.org/10.14309/00000434-200709002-00149" @default.
W2912678344 hasPublicationYear "2007" @default.
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