FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912679950> ?p ?o ?g. }

• W2912679950 endingPage "932" @default.
• W2912679950 startingPage "931" @default.
• W2912679950 abstract "The data collection and analysis of the Salmeterol Multicenter Asthma Research Trial were conducted with rigor, scientific integrity, and without known bias; our article was a transparent, peer-reviewed communication designed to inform health-care practitioners. Dr. Seymour questions why data from the 28-week treatment period plus a 6-month follow-up period were included along with data from the 28-week treatment period. The protocol included a 6-month follow-up because patients received 6 months of therapy and underwent minimal procedures to retrieve unused medication. It is well-recognized that medication therapy compliance is poor; therefore, patients may have had study medication left and continued to take it beyond the 28-week period. Although it is possible that patients receiving placebo may have initiated salmeterol therapy after the study, the only planned analysis included the data from the 28-week treatment period plus the additional 6-month follow-up period, which were provided to an independent Data Safety Monitoring Board and subsequently to the US Food and Drug Administration (FDA). After study termination and the reporting on the interim analysis, further discussions with the US FDA led to an agreement to focus the analysis on the 28-week treatment period, although no substantial differences exist between the analysis of the 28-week treatment period and that of the 28-week treatment period plus the 6-month follow-up period. Dr. Seymour further questions the data reported for the two distinct phases. These data were acknowledged in the article as being exploratory. It is well-recognized that study design and recruitment approaches can lead to confounding in studies. Switching from media-driven recruitment, yielding 13 asthma-related deaths in 15,342 patients (phase I), to investigator-driven recruitment, yielding 3 asthma-related deaths in 11,013 patients (phase II), suggests that the recruitment approach may have affected outcomes. Furthermore, the quality of care and the physician-patient relationship can affect outcomes and were likely different between the phases, providing the scientific basis for this analysis. We agree that interested readers should review the breadth of the data and the proceedings of the US FDA advisory committee that was convened to discuss long-acting β-agonists. Comments on the Salmeterol Multicenter Asthma Research TrialCHESTVol. 130Issue 3PreviewThe Salmeterol Multicenter Asthma Research Trial (SMART)1 was initiated to further explore the signal for asthma-related death seen in the Serevent Nationwide Surveillance Study2 in light of US postmarketing reports3 of asthma fatalities associated with salmeterol. SMART confirms the earlier findings that salmeterol use leads to an increased incidence of asthma-related death. We have two comments on the report by Nelson et al.1 Full-Text PDF" @default.
• W2912679950 created "2019-02-21" @default.
• W2912679950 creator A5004903602 @default.
• W2912679950 creator A5021609170 @default.
• W2912679950 date "2006-09-01" @default.
• W2912679950 modified "2023-10-16" @default.
• W2912679950 title "Comments on the Salmeterol Multicenter Asthma Research Trial" @default.
• W2912679950 doi "https://doi.org/10.1378/chest.130.3.931" @default.
• W2912679950 hasPublicationYear "2006" @default.
• W2912679950 type Work @default.
• W2912679950 sameAs 2912679950 @default.
• W2912679950 citedByCount "0" @default.
• W2912679950 crossrefType "journal-article" @default.
• W2912679950 hasAuthorship W2912679950A5004903602 @default.
• W2912679950 hasAuthorship W2912679950A5021609170 @default.
• W2912679950 hasBestOaLocation W29126799501 @default.
• W2912679950 hasConcept C126322002 @default.
• W2912679950 hasConcept C142724271 @default.
• W2912679950 hasConcept C166957645 @default.
• W2912679950 hasConcept C187212893 @default.
• W2912679950 hasConcept C204787440 @default.
• W2912679950 hasConcept C27081682 @default.
• W2912679950 hasConcept C2776042228 @default.
• W2912679950 hasConcept C2776719499 @default.
• W2912679950 hasConcept C2776957806 @default.
• W2912679950 hasConcept C512399662 @default.
• W2912679950 hasConcept C535046627 @default.
• W2912679950 hasConcept C61943457 @default.
• W2912679950 hasConcept C71924100 @default.
• W2912679950 hasConcept C73751289 @default.
• W2912679950 hasConcept C95457728 @default.
• W2912679950 hasConceptScore W2912679950C126322002 @default.
• W2912679950 hasConceptScore W2912679950C142724271 @default.
• W2912679950 hasConceptScore W2912679950C166957645 @default.
• W2912679950 hasConceptScore W2912679950C187212893 @default.
• W2912679950 hasConceptScore W2912679950C204787440 @default.
• W2912679950 hasConceptScore W2912679950C27081682 @default.
• W2912679950 hasConceptScore W2912679950C2776042228 @default.
• W2912679950 hasConceptScore W2912679950C2776719499 @default.
• W2912679950 hasConceptScore W2912679950C2776957806 @default.
• W2912679950 hasConceptScore W2912679950C512399662 @default.
• W2912679950 hasConceptScore W2912679950C535046627 @default.
• W2912679950 hasConceptScore W2912679950C61943457 @default.
• W2912679950 hasConceptScore W2912679950C71924100 @default.
• W2912679950 hasConceptScore W2912679950C73751289 @default.
• W2912679950 hasConceptScore W2912679950C95457728 @default.
• W2912679950 hasIssue "3" @default.
• W2912679950 hasLocation W29126799501 @default.
• W2912679950 hasOpenAccess W2912679950 @default.
• W2912679950 hasPrimaryLocation W29126799501 @default.
• W2912679950 hasRelatedWork W1974833954 @default.
• W2912679950 hasRelatedWork W2023402573 @default.
• W2912679950 hasRelatedWork W2063574838 @default.
• W2912679950 hasRelatedWork W2068336543 @default.
• W2912679950 hasRelatedWork W2084558932 @default.
• W2912679950 hasRelatedWork W2086152322 @default.
• W2912679950 hasRelatedWork W2101471792 @default.
• W2912679950 hasRelatedWork W2105924009 @default.
• W2912679950 hasRelatedWork W2127153601 @default.
• W2912679950 hasRelatedWork W66630131 @default.
• W2912679950 hasVolume "130" @default.
• W2912679950 isParatext "false" @default.
• W2912679950 isRetracted "false" @default.
• W2912679950 magId "2912679950" @default.
• W2912679950 workType "article" @default.