Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912680147> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2912680147 endingPage "218" @default.
- W2912680147 startingPage "211" @default.
- W2912680147 abstract "Cell migration is essential for proper development and the defense against pathogens. Our previous work detailed a pathway of REversion-inducing-Cysteine-rich protein with Kazal motifs (RECK) isoform-mediated invasion in which a shorter RECK protein competes with MMP9 for interaction with the canonical RECK protein on the cell surface. Here we demonstrate that the mechanism through which RECK isoforms affect cell migration is mediated through changes in the levels of post-translational modifications (PTM) of α-tubulin. We show that both the canonical and short RECK isoforms modulate levels of tubulin acetylation and detyrosination. We demonstrate that these changes are sufficient to modulate the rate of fibroblast migration. If these tubulin PTMs are not altered, the effects of the canonical RECK isoform on cell migration are reversed. In defining the molecular pathway linking RECK and tubulin PTMs, we found that MMP9 and integrin activity both act as upstream regulators of tubulin acetylation and detyrosination. Overall, we propose a mechanism in which RECK isoforms on the cell surface have opposing effects on cell migration through MMP9-modulated changes to integrin-extracellular matrix (ECM) interactions that, in turn, affect microtubule PTMs." @default.
- W2912680147 created "2019-02-21" @default.
- W2912680147 creator A5031522901 @default.
- W2912680147 creator A5046514514 @default.
- W2912680147 creator A5075034585 @default.
- W2912680147 date "2019-03-01" @default.
- W2912680147 modified "2023-09-25" @default.
- W2912680147 title "RECK isoforms differentially regulate fibroblast migration by modulating tubulin post-translational modifications" @default.
- W2912680147 cites W1521833917 @default.
- W2912680147 cites W1585324347 @default.
- W2912680147 cites W1981549228 @default.
- W2912680147 cites W1984374880 @default.
- W2912680147 cites W2023495875 @default.
- W2912680147 cites W2052907252 @default.
- W2912680147 cites W2053691011 @default.
- W2912680147 cites W2064959533 @default.
- W2912680147 cites W2066578425 @default.
- W2912680147 cites W2072853614 @default.
- W2912680147 cites W2081923855 @default.
- W2912680147 cites W2091285142 @default.
- W2912680147 cites W2106488950 @default.
- W2912680147 cites W2126473448 @default.
- W2912680147 cites W2152667145 @default.
- W2912680147 cites W2163059327 @default.
- W2912680147 cites W2605162336 @default.
- W2912680147 cites W2770502839 @default.
- W2912680147 cites W2775650492 @default.
- W2912680147 cites W2806375681 @default.
- W2912680147 doi "https://doi.org/10.1016/j.bbrc.2019.01.063" @default.
- W2912680147 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7217981" @default.
- W2912680147 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30704758" @default.
- W2912680147 hasPublicationYear "2019" @default.
- W2912680147 type Work @default.
- W2912680147 sameAs 2912680147 @default.
- W2912680147 citedByCount "3" @default.
- W2912680147 countsByYear W29126801472020 @default.
- W2912680147 countsByYear W29126801472021 @default.
- W2912680147 crossrefType "journal-article" @default.
- W2912680147 hasAuthorship W2912680147A5031522901 @default.
- W2912680147 hasAuthorship W2912680147A5046514514 @default.
- W2912680147 hasAuthorship W2912680147A5075034585 @default.
- W2912680147 hasBestOaLocation W29126801472 @default.
- W2912680147 hasConcept C104317684 @default.
- W2912680147 hasConcept C119157956 @default.
- W2912680147 hasConcept C127561419 @default.
- W2912680147 hasConcept C137738243 @default.
- W2912680147 hasConcept C1491633281 @default.
- W2912680147 hasConcept C189165786 @default.
- W2912680147 hasConcept C20418707 @default.
- W2912680147 hasConcept C2775997469 @default.
- W2912680147 hasConcept C53345823 @default.
- W2912680147 hasConcept C55493867 @default.
- W2912680147 hasConcept C84425145 @default.
- W2912680147 hasConcept C86803240 @default.
- W2912680147 hasConcept C95444343 @default.
- W2912680147 hasConceptScore W2912680147C104317684 @default.
- W2912680147 hasConceptScore W2912680147C119157956 @default.
- W2912680147 hasConceptScore W2912680147C127561419 @default.
- W2912680147 hasConceptScore W2912680147C137738243 @default.
- W2912680147 hasConceptScore W2912680147C1491633281 @default.
- W2912680147 hasConceptScore W2912680147C189165786 @default.
- W2912680147 hasConceptScore W2912680147C20418707 @default.
- W2912680147 hasConceptScore W2912680147C2775997469 @default.
- W2912680147 hasConceptScore W2912680147C53345823 @default.
- W2912680147 hasConceptScore W2912680147C55493867 @default.
- W2912680147 hasConceptScore W2912680147C84425145 @default.
- W2912680147 hasConceptScore W2912680147C86803240 @default.
- W2912680147 hasConceptScore W2912680147C95444343 @default.
- W2912680147 hasFunder F4320332502 @default.
- W2912680147 hasFunder F4320337354 @default.
- W2912680147 hasIssue "2" @default.
- W2912680147 hasLocation W29126801471 @default.
- W2912680147 hasLocation W29126801472 @default.
- W2912680147 hasLocation W29126801473 @default.
- W2912680147 hasLocation W29126801474 @default.
- W2912680147 hasLocation W29126801475 @default.
- W2912680147 hasOpenAccess W2912680147 @default.
- W2912680147 hasPrimaryLocation W29126801471 @default.
- W2912680147 hasRelatedWork W1028951263 @default.
- W2912680147 hasRelatedWork W1555013184 @default.
- W2912680147 hasRelatedWork W1705189476 @default.
- W2912680147 hasRelatedWork W2066752826 @default.
- W2912680147 hasRelatedWork W2093968366 @default.
- W2912680147 hasRelatedWork W2142300972 @default.
- W2912680147 hasRelatedWork W2892160808 @default.
- W2912680147 hasRelatedWork W310958704 @default.
- W2912680147 hasRelatedWork W3112822293 @default.
- W2912680147 hasRelatedWork W3198024778 @default.
- W2912680147 hasVolume "510" @default.
- W2912680147 isParatext "false" @default.
- W2912680147 isRetracted "false" @default.
- W2912680147 magId "2912680147" @default.
- W2912680147 workType "article" @default.