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- W2912681691 endingPage "152" @default.
- W2912681691 startingPage "152" @default.
- W2912681691 abstract "Background: Ischemia-Reperfusion (I/R) injury is the tissue damage that results from re-oxygenation of ischemic tissues. There are many players that contribute to I/R injury. One of these factors is the family of microRNAs (miRNAs), which are currently being heavily studied. This review aims to critically summarize the latest papers that attributed roles of certain miRNAs in I/R injury, particularly in diabetic conditions and dissect their potential as novel pharmacologic targets in the treatment and management of diabetes. Methods: PubMed was searched for publications containing microRNA and I/R, in the absence or presence of diabetes. All papers that provided sufficient evidence linking miRNA with I/R, especially in the context of diabetes, were selected. Several miRNAs are found to be either pro-apoptotic, as in the case of miR-34a, miR-144, miR-155, and miR-200, or anti-apoptotic, as in the case of miR-210, miR-21, and miR-146a. Here, we further dissect the evidence that shows diverse cell-context dependent effects of these miRNAs, particularly in cardiomyocytes, endothelial, or leukocytes. We also provide insight into cases where the possibility of having two miRNAs working together to intensify a given response is noted. Conclusions: This review arrives at the conclusion that the utilization of miRNAs as translational agents or pharmaco-targets in treating I/R injury in diabetic patients is promising and becoming increasingly clearer." @default.
- W2912681691 created "2019-02-21" @default.
- W2912681691 creator A5020493795 @default.
- W2912681691 creator A5023529414 @default.
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- W2912681691 creator A5043587300 @default.
- W2912681691 creator A5055298302 @default.
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- W2912681691 creator A5070363714 @default.
- W2912681691 creator A5081142003 @default.
- W2912681691 creator A5082685876 @default.
- W2912681691 creator A5086381594 @default.
- W2912681691 date "2019-02-12" @default.
- W2912681691 modified "2023-10-01" @default.
- W2912681691 title "MicroRNAs as Potential Pharmaco-targets in Ischemia-Reperfusion Injury Compounded by Diabetes" @default.
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