Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912682365> ?p ?o ?g. }
- W2912682365 endingPage "148" @default.
- W2912682365 startingPage "134" @default.
- W2912682365 abstract "Objectives: The present paper aimed to assist physicians in the accurate choice among second-generation agents (SGAs) for patients with cardiovascular disease (CVD).Methods: We reviewed the published pharmacokinetic (PK) and pharmacodynamic (PD) clinical data that report potential -or absence of- drug interactions between second-generation agents (SGAs) and CVD drugs most commonly used in cardiology, including antiplatelet drugs and anticoagulants, statins, beta-blockers, angiotensin-converting enzyme inhibitors, calcium channel blockers, diuretics and the antiarrhythmic drugs amiodarone and digoxin.We also reviewed the cardiovascular safety profile that has been published for each class of SGAs and side effects reported by patients with CVD. Results: Most relevant PK/PD data about SGAs and CVD drugs are based on small studies or detailed case reports. In many cases, the drug interactions are at most assessed in healthy volunteers so that the clinical relevance of findings needs further investigation in patients with CVD. Case reports of serious, sometimes fatal reactions due to concomitant administration of certain drugs require careful consideration.The major cardiac side effects of SGAs include HR increase, postural hypotension and slight prolongation of the intraventricular conduction time and QT interval. On normal dosage of antidepressants, both advanced heart block and ventricular arrhythmias could occur in patients with severe heart disease, together with clinically important loss of myocardial contractile force.Conclusions: Data reported in the present review should help physicians about their decision-making processes that govern SGAs use in CVD patients." @default.
- W2912682365 created "2019-02-21" @default.
- W2912682365 creator A5005289260 @default.
- W2912682365 date "2019-02-01" @default.
- W2912682365 modified "2023-09-25" @default.
- W2912682365 title "Choosing among second-generation antidepressant treatments for depressed patients with cardiac diseases" @default.
- W2912682365 cites W1268568596 @default.
- W2912682365 cites W1430508933 @default.
- W2912682365 cites W1586142842 @default.
- W2912682365 cites W1901734004 @default.
- W2912682365 cites W1906251018 @default.
- W2912682365 cites W1950070193 @default.
- W2912682365 cites W1964022439 @default.
- W2912682365 cites W1967900132 @default.
- W2912682365 cites W1968073258 @default.
- W2912682365 cites W1973114177 @default.
- W2912682365 cites W1973163598 @default.
- W2912682365 cites W1974748254 @default.
- W2912682365 cites W1975318977 @default.
- W2912682365 cites W1975656763 @default.
- W2912682365 cites W1978084418 @default.
- W2912682365 cites W1978257720 @default.
- W2912682365 cites W1980168340 @default.
- W2912682365 cites W1980235398 @default.
- W2912682365 cites W1980240868 @default.
- W2912682365 cites W1980754951 @default.
- W2912682365 cites W1980779249 @default.
- W2912682365 cites W1981779660 @default.
- W2912682365 cites W1987151928 @default.
- W2912682365 cites W1989028229 @default.
- W2912682365 cites W1990912030 @default.
- W2912682365 cites W1995135949 @default.
- W2912682365 cites W1998979412 @default.
- W2912682365 cites W2000370294 @default.
- W2912682365 cites W2002097094 @default.
- W2912682365 cites W2010277768 @default.
- W2912682365 cites W2011087220 @default.
- W2912682365 cites W2011662378 @default.
- W2912682365 cites W2015010727 @default.
- W2912682365 cites W2017181291 @default.
- W2912682365 cites W2018080987 @default.
- W2912682365 cites W2018688347 @default.
- W2912682365 cites W2019482418 @default.
- W2912682365 cites W2023761185 @default.
- W2912682365 cites W2024012851 @default.
- W2912682365 cites W2024993254 @default.
- W2912682365 cites W2029910428 @default.
- W2912682365 cites W2032884131 @default.
- W2912682365 cites W2033137045 @default.
- W2912682365 cites W2033440372 @default.
- W2912682365 cites W2035697132 @default.
- W2912682365 cites W2036891077 @default.
- W2912682365 cites W2037833111 @default.
- W2912682365 cites W2044170764 @default.
- W2912682365 cites W2047858235 @default.
- W2912682365 cites W2052109051 @default.
- W2912682365 cites W2052222072 @default.
- W2912682365 cites W2055735784 @default.
- W2912682365 cites W2062354466 @default.
- W2912682365 cites W2062844762 @default.
- W2912682365 cites W2064166778 @default.
- W2912682365 cites W2064210134 @default.
- W2912682365 cites W2064403414 @default.
- W2912682365 cites W2066406291 @default.
- W2912682365 cites W2074067141 @default.
- W2912682365 cites W2074133854 @default.
- W2912682365 cites W2077205688 @default.
- W2912682365 cites W2077418460 @default.
- W2912682365 cites W2079782826 @default.
- W2912682365 cites W2080404498 @default.
- W2912682365 cites W2084002386 @default.
- W2912682365 cites W2086467579 @default.
- W2912682365 cites W2086920841 @default.
- W2912682365 cites W2090469905 @default.
- W2912682365 cites W2091528564 @default.
- W2912682365 cites W2092781992 @default.
- W2912682365 cites W2098992041 @default.
- W2912682365 cites W2101820523 @default.
- W2912682365 cites W2106292851 @default.
- W2912682365 cites W2106618845 @default.
- W2912682365 cites W2108928593 @default.
- W2912682365 cites W2110410985 @default.
- W2912682365 cites W2111868302 @default.
- W2912682365 cites W2116725617 @default.
- W2912682365 cites W2119176600 @default.
- W2912682365 cites W2120966987 @default.
- W2912682365 cites W2123808537 @default.
- W2912682365 cites W2124384934 @default.
- W2912682365 cites W2125434307 @default.
- W2912682365 cites W2129478148 @default.
- W2912682365 cites W2132965853 @default.
- W2912682365 cites W2134817114 @default.
- W2912682365 cites W2135310457 @default.
- W2912682365 cites W2135361148 @default.
- W2912682365 cites W2141625451 @default.
- W2912682365 cites W2144580286 @default.
- W2912682365 cites W2145958178 @default.
- W2912682365 cites W2149901252 @default.