Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912682777> ?p ?o ?g. }
- W2912682777 endingPage "1854" @default.
- W2912682777 startingPage "1848" @default.
- W2912682777 abstract "Experimental models have demonstrated that immune surveillance by cytotoxic lymphocytes can protect from spontaneous neoplasms and cancer. In humans, defective lymphocyte cytotoxicity is associated with the development of hemophagocytic lymphohistiocytosis, a hyperinflammatory syndrome. However, to the best of the authors' knowledge, the degree to which human lymphocyte cytotoxicity protects from cancer remains unclear. In the current study, the authors examined the risk of lymphoma attributable to haploinsufficiency in a gene required for lymphocyte cytotoxicity.The authors exploited a founder effect of an UNC13D inversion, which abolishes Munc13-4 expression and causes hemophagocytic lymphohistiocytosis in an autosomal recessive manner. Within 2 epidemiological screening programs in northern Sweden, an area demonstrating a founder effect of this specific UNC13D mutation, all individuals with a diagnosis of lymphoma (487 patients) and matched controls (1844 controls) were assessed using polymerase chain reaction for carrier status.Among 487 individuals with lymphoma, 15 (3.1%) were heterozygous carriers of the UNC13D inversion, compared with 18 controls (1.0%) (odds ratio, 3.0; P = .002). It is interesting to note that a higher risk of lymphoma was attributed to female carriers (odds ratio, 3.7; P = .004).Establishing a high regional prevalence of the UNC13D inversion, the authors have reported an overrepresentation of this mutation in individuals with lymphoma. Therefore, the results of the current study indicate that haploinsufficiency of a gene required for lymphocyte cytotoxicity can predispose patients to lymphoma, suggesting the importance of cytotoxic lymphocyte-mediated surveillance of cancer. Furthermore, the results of the current study suggest that female carriers are more susceptible to lymphoma." @default.
- W2912682777 created "2019-02-21" @default.
- W2912682777 creator A5000083974 @default.
- W2912682777 creator A5007562169 @default.
- W2912682777 creator A5015561854 @default.
- W2912682777 creator A5022577576 @default.
- W2912682777 creator A5026704231 @default.
- W2912682777 creator A5044334708 @default.
- W2912682777 creator A5056352517 @default.
- W2912682777 creator A5078627198 @default.
- W2912682777 date "2019-02-13" @default.
- W2912682777 modified "2023-10-15" @default.
- W2912682777 title "Haploinsufficiency of <i>UNC13D</i> increases the risk of lymphoma" @default.
- W2912682777 cites W1530342027 @default.
- W2912682777 cites W1791103558 @default.
- W2912682777 cites W1908769349 @default.
- W2912682777 cites W1967229707 @default.
- W2912682777 cites W1982971190 @default.
- W2912682777 cites W1988905504 @default.
- W2912682777 cites W1988993642 @default.
- W2912682777 cites W2031648930 @default.
- W2912682777 cites W2044972453 @default.
- W2912682777 cites W2046972425 @default.
- W2912682777 cites W2049491375 @default.
- W2912682777 cites W2058275143 @default.
- W2912682777 cites W2058793954 @default.
- W2912682777 cites W2066519398 @default.
- W2912682777 cites W2068425655 @default.
- W2912682777 cites W2085367090 @default.
- W2912682777 cites W2088813214 @default.
- W2912682777 cites W2090202760 @default.
- W2912682777 cites W2098005365 @default.
- W2912682777 cites W2117692326 @default.
- W2912682777 cites W2124930517 @default.
- W2912682777 cites W2131771270 @default.
- W2912682777 cites W2138737838 @default.
- W2912682777 cites W2144441835 @default.
- W2912682777 cites W2156034697 @default.
- W2912682777 cites W2160276388 @default.
- W2912682777 cites W2182534661 @default.
- W2912682777 cites W2268797426 @default.
- W2912682777 cites W2332340631 @default.
- W2912682777 cites W2345276663 @default.
- W2912682777 cites W2414459762 @default.
- W2912682777 cites W2518536270 @default.
- W2912682777 cites W2792941879 @default.
- W2912682777 doi "https://doi.org/10.1002/cncr.32011" @default.
- W2912682777 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6593970" @default.
- W2912682777 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30758854" @default.
- W2912682777 hasPublicationYear "2019" @default.
- W2912682777 type Work @default.
- W2912682777 sameAs 2912682777 @default.
- W2912682777 citedByCount "8" @default.
- W2912682777 countsByYear W29126827772020 @default.
- W2912682777 countsByYear W29126827772021 @default.
- W2912682777 countsByYear W29126827772022 @default.
- W2912682777 countsByYear W29126827772023 @default.
- W2912682777 crossrefType "journal-article" @default.
- W2912682777 hasAuthorship W2912682777A5000083974 @default.
- W2912682777 hasAuthorship W2912682777A5007562169 @default.
- W2912682777 hasAuthorship W2912682777A5015561854 @default.
- W2912682777 hasAuthorship W2912682777A5022577576 @default.
- W2912682777 hasAuthorship W2912682777A5026704231 @default.
- W2912682777 hasAuthorship W2912682777A5044334708 @default.
- W2912682777 hasAuthorship W2912682777A5056352517 @default.
- W2912682777 hasAuthorship W2912682777A5078627198 @default.
- W2912682777 hasBestOaLocation W29126827771 @default.
- W2912682777 hasConcept C104317684 @default.
- W2912682777 hasConcept C126322002 @default.
- W2912682777 hasConcept C127716648 @default.
- W2912682777 hasConcept C143998085 @default.
- W2912682777 hasConcept C156957248 @default.
- W2912682777 hasConcept C203014093 @default.
- W2912682777 hasConcept C2777761686 @default.
- W2912682777 hasConcept C2779079688 @default.
- W2912682777 hasConcept C2779134260 @default.
- W2912682777 hasConcept C2779338263 @default.
- W2912682777 hasConcept C502942594 @default.
- W2912682777 hasConcept C54355233 @default.
- W2912682777 hasConcept C68838962 @default.
- W2912682777 hasConcept C71924100 @default.
- W2912682777 hasConcept C86803240 @default.
- W2912682777 hasConceptScore W2912682777C104317684 @default.
- W2912682777 hasConceptScore W2912682777C126322002 @default.
- W2912682777 hasConceptScore W2912682777C127716648 @default.
- W2912682777 hasConceptScore W2912682777C143998085 @default.
- W2912682777 hasConceptScore W2912682777C156957248 @default.
- W2912682777 hasConceptScore W2912682777C203014093 @default.
- W2912682777 hasConceptScore W2912682777C2777761686 @default.
- W2912682777 hasConceptScore W2912682777C2779079688 @default.
- W2912682777 hasConceptScore W2912682777C2779134260 @default.
- W2912682777 hasConceptScore W2912682777C2779338263 @default.
- W2912682777 hasConceptScore W2912682777C502942594 @default.
- W2912682777 hasConceptScore W2912682777C54355233 @default.
- W2912682777 hasConceptScore W2912682777C68838962 @default.
- W2912682777 hasConceptScore W2912682777C71924100 @default.
- W2912682777 hasConceptScore W2912682777C86803240 @default.
- W2912682777 hasFunder F4320306967 @default.