Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912682829> ?p ?o ?g. }
- W2912682829 endingPage "104" @default.
- W2912682829 startingPage "94" @default.
- W2912682829 abstract "Activated Akt and ERK signaling pathways are closely related to breast cancer progression, and Akt or ERK inhibition induces cell senescence. However, the crosstalk between the Akt and ERK signaling pathways in cell senescence and how to simultaneously suppress Akt and ERK signaling in triple-negative breast cancer (TNBC) are undefined. In this study, we found that norcantharidin (NCTD) effectively induced cell senescence and cell cycle arrest in TNBC in vitro, which was accompanied by a decline in phosphorylated Akt and ERK1/2 and a rise in p21 and p16. The inhibitors LY294002 and U0126 imitated the effect of NCTD when these two inhibitors were combined regardless of crosstalk between these two signaling pathways. In addition, NCTD inhibited the growth of xenografts via downregulation of phosphorylated Akt and ERK1/2 and upregulation of p21 in vivo. However, NCTD upregulated the level of soluble signaling factors of the senescence-associated secretory phenotype (SASP) in a NF-κB-independent manner. Collectively, these findings demonstrate that NCTD induced cell senescence and cell cycle arrest mainly by simultaneously blocking Akt and ERK signaling in TNBC, suggesting that NCTD may be used as a potential adjuvant therapy in TNBC." @default.
- W2912682829 created "2019-02-21" @default.
- W2912682829 creator A5026174200 @default.
- W2912682829 creator A5035568306 @default.
- W2912682829 creator A5039022069 @default.
- W2912682829 creator A5039366205 @default.
- W2912682829 creator A5051430265 @default.
- W2912682829 creator A5052878574 @default.
- W2912682829 creator A5053736386 @default.
- W2912682829 creator A5064252005 @default.
- W2912682829 creator A5077741672 @default.
- W2912682829 creator A5082185903 @default.
- W2912682829 date "2019-04-01" @default.
- W2912682829 modified "2023-10-18" @default.
- W2912682829 title "Dual inhibition of Akt and ERK signaling induces cell senescence in triple-negative breast cancer" @default.
- W2912682829 cites W1971250890 @default.
- W2912682829 cites W1980157584 @default.
- W2912682829 cites W1992399640 @default.
- W2912682829 cites W1995022664 @default.
- W2912682829 cites W1996113298 @default.
- W2912682829 cites W1997032085 @default.
- W2912682829 cites W1998203489 @default.
- W2912682829 cites W2010098991 @default.
- W2912682829 cites W2015512041 @default.
- W2912682829 cites W2018406453 @default.
- W2912682829 cites W2027880353 @default.
- W2912682829 cites W2029192858 @default.
- W2912682829 cites W2030933825 @default.
- W2912682829 cites W2032417823 @default.
- W2912682829 cites W2039452867 @default.
- W2912682829 cites W2039924299 @default.
- W2912682829 cites W2043560779 @default.
- W2912682829 cites W2046543574 @default.
- W2912682829 cites W2073308507 @default.
- W2912682829 cites W2077450385 @default.
- W2912682829 cites W2082167659 @default.
- W2912682829 cites W2091369486 @default.
- W2912682829 cites W2096027508 @default.
- W2912682829 cites W2096283457 @default.
- W2912682829 cites W2105437003 @default.
- W2912682829 cites W2115852450 @default.
- W2912682829 cites W2117692326 @default.
- W2912682829 cites W2118523851 @default.
- W2912682829 cites W2128124648 @default.
- W2912682829 cites W2128488838 @default.
- W2912682829 cites W2130641919 @default.
- W2912682829 cites W2134797116 @default.
- W2912682829 cites W2141283414 @default.
- W2912682829 cites W2142799999 @default.
- W2912682829 cites W2155730420 @default.
- W2912682829 cites W2211890826 @default.
- W2912682829 cites W2257501429 @default.
- W2912682829 cites W2286447252 @default.
- W2912682829 cites W2316365641 @default.
- W2912682829 cites W2469003638 @default.
- W2912682829 cites W2536094308 @default.
- W2912682829 cites W2543650474 @default.
- W2912682829 cites W2547041966 @default.
- W2912682829 cites W2556093773 @default.
- W2912682829 cites W2575815939 @default.
- W2912682829 cites W2580715679 @default.
- W2912682829 cites W2619847932 @default.
- W2912682829 cites W2621171915 @default.
- W2912682829 cites W2769327984 @default.
- W2912682829 cites W2771013386 @default.
- W2912682829 cites W2781525129 @default.
- W2912682829 cites W2802580214 @default.
- W2912682829 cites W2803901263 @default.
- W2912682829 cites W2885742593 @default.
- W2912682829 cites W2890701503 @default.
- W2912682829 cites W4238970051 @default.
- W2912682829 doi "https://doi.org/10.1016/j.canlet.2019.02.004" @default.
- W2912682829 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30742942" @default.
- W2912682829 hasPublicationYear "2019" @default.
- W2912682829 type Work @default.
- W2912682829 sameAs 2912682829 @default.
- W2912682829 citedByCount "25" @default.
- W2912682829 countsByYear W29126828292019 @default.
- W2912682829 countsByYear W29126828292020 @default.
- W2912682829 countsByYear W29126828292021 @default.
- W2912682829 countsByYear W29126828292022 @default.
- W2912682829 countsByYear W29126828292023 @default.
- W2912682829 crossrefType "journal-article" @default.
- W2912682829 hasAuthorship W2912682829A5026174200 @default.
- W2912682829 hasAuthorship W2912682829A5035568306 @default.
- W2912682829 hasAuthorship W2912682829A5039022069 @default.
- W2912682829 hasAuthorship W2912682829A5039366205 @default.
- W2912682829 hasAuthorship W2912682829A5051430265 @default.
- W2912682829 hasAuthorship W2912682829A5052878574 @default.
- W2912682829 hasAuthorship W2912682829A5053736386 @default.
- W2912682829 hasAuthorship W2912682829A5064252005 @default.
- W2912682829 hasAuthorship W2912682829A5077741672 @default.
- W2912682829 hasAuthorship W2912682829A5082185903 @default.
- W2912682829 hasConcept C104317684 @default.
- W2912682829 hasConcept C105696609 @default.
- W2912682829 hasConcept C121608353 @default.
- W2912682829 hasConcept C127561419 @default.
- W2912682829 hasConcept C1491633281 @default.