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- W2912683143 abstract "Therapeutic drug monitoring has been used historically for drugs with a narrow therapeutic window (e.g. warfarin), where subtherapeutic drug exposure results in impaired efficacy and is related to toxicity. Emerging evidence for therapeutic monoclonal antibodies shows the importance of adequate drug exposure for achieving outcomes in chronic inflammatory diseases, especially inflammatory bowel diseases. Given the apparent exposure-response relationship observed for tumor necrosis factor antagonists, various methods have been proposed to optimize dosing to achieve better outcomes. Proactive therapeutic drug monitoring can be done both during induction therapy (to increase primary response and remission rates) or maintenance therapy (to achieve sustained response and avoid loss of response). Different drug concentration thresholds have been proposed in the literature that are associated with outcomes and thus one approach is to change the dose based on the observed systemic drug concentration." @default.
- W2912683143 created "2019-02-21" @default.
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- W2912683143 date "2019-02-15" @default.
- W2912683143 modified "2023-09-25" @default.
- W2912683143 title "Pharmacokinetics-Based Dosing for Therapeutic Monoclonal Antibodies in Inflammatory Bowel Disease" @default.
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- W2912683143 doi "https://doi.org/10.1002/9781119289234.ch11" @default.
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