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- W2912684486 endingPage "e0211041" @default.
- W2912684486 startingPage "e0211041" @default.
- W2912684486 abstract "Neutrophils display rapid and potent innate immune responses in various diseases. Tumor-associated neutrophils (TANs) however either induce or overcome immunosuppressive functions of the tumor microenvironment through complex tumor-stroma crosstalk. We developed a mathematical model to address the question of how phenotypic alterations between tumor suppressive N1 TANS, and tumor promoting N2 TANs affect nonlinear tumor growth in a complex tumor microenvironment. The model provides a visual display of the complex behavior of populations of TANs and tumors in response to various TGF-β and IFN-β stimuli. In addition, the effect of anti-tumor drug administration is incorporated in the model in an effort to achieve optimal anti-tumor efficacy. The simulation results from the mathematical model were in good agreement with experimental data. We found that the N2-to-N1 ratio (N21R) index is positively correlated with aggressive tumor growth, suggesting that this may be a good prognostic factor. We also found that the antitumor efficacy increases when the relative ratio (Dap) of delayed apoptotic cell death of N1 and N2 TANs is either very small or relatively large, providing a basis for therapeutically targeting prometastatic N2 TANs." @default.
- W2912684486 created "2019-02-21" @default.
- W2912684486 creator A5008836248 @default.
- W2912684486 creator A5020170755 @default.
- W2912684486 creator A5026623974 @default.
- W2912684486 creator A5030467675 @default.
- W2912684486 creator A5077829672 @default.
- W2912684486 date "2019-01-28" @default.
- W2912684486 modified "2023-09-25" @default.
- W2912684486 title "Role of tumor-associated neutrophils in regulation of tumor growth in lung cancer development: A mathematical model" @default.
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