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- W2912684718 abstract "Potential conflict of interest: Nothing to report. We thank Dr. Pedersen and colleagues for their interest in our work, and we welcome the external validation of the Royal Free Hospital Cirrhosis Glomerular Filtration Rate (GFR).1 As a general comment, the equation performs very well in this independent cohort and only slightly underestimates true GFR, unlike widely used formulas such as the Modification of Diet in Renal Disease. We would also like to discuss a few additional points. First, since the publication of our article, we have discovered an error in the originally reported formula and we have submitted an erratum, which is in press. The correct formula should read: GFR=45.9×(creatinine−0.836)×(urea−0.229)×(INR−0.113)×(age−0.129)×(sodium0.972)×1.236(if male)×0.92(if moderate/severe ascites).We presume that the GFR underestimation will be less pronounced should the authors use the corrected formula. Second, 51‐chromium‐ethylene diamine tetraacetic acid measurement in patients with ascites is more reliable when plasma samples are taken up to 24 hours postinjection rather than just 6 hours.2 This could have resulted in small inaccuracy of the “gold‐standard” measurement in the Danish cohort. Third, it would be of interest if the authors could show how the Royal Free Hospital cirrhosis GFR performs compared to other widely used GFR formulas in this independent data set. This would encourage a more widespread use of this equation. Ultimately, as we mentioned in our article, it would be valuable to explore whether the incorporation of this cirrhosis‐specific GFR equation instead of creatinine in prognostic scores such as Model for End‐Stage Liver Disease improves their performance; we are in the process of testing this using data from the NHS British Transplant database." @default.
- W2912684718 created "2019-02-21" @default.
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- W2912684718 date "2017-08-26" @default.
- W2912684718 modified "2023-09-26" @default.
- W2912684718 title "Reply" @default.
- W2912684718 cites W2317301101 @default.
- W2912684718 cites W2321925611 @default.
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- W2912684718 doi "https://doi.org/10.1002/hep.29391" @default.
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