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• W2912685222 abstract "Abstract Numerous studies have focused on the PI3K/AKT/mTOR pathway in estrogen receptor positive (ER) breast cancer (BC), as a linear signal transduction pathway and reported its association with worse clinical outcomes. We developed gene signatures that reflect the level of expression of phosphorylated-Serine473-AKT (pAKT) and phosphorylated-Serine2448-mTOR (p-mTOR) separately, capturing their corresponding level of pathway activation. Our analysis revealed that the pAKT pathway activation was associated with luminal A BC while the p-mTOR pathway activation was more associated with luminal B BC (Kruskal–Wallis test p < 10 −10 ). pAKT pathway activation was significantly associated with better outcomes (multivariable HR, 0.79; 95%CI, 0.74–0.85; p = 2.5 × 10 −10 ) and PIK3CA mutations ( p = 0.0001) whereas p-mTOR pathway activation showed worse outcomes (multivariable HR,1.1; 95%CI, 1.1–1.2; p = 9.9 × 10 −4 ) and associated with p53 mutations ( p = 0.04). in conclusion, our data show that pAKT and p-mTOR pathway activation have differing impact on prognosis and suggest that they are not linearly connected in luminal breast cancers." @default.
• W2912685222 created "2019-02-21" @default.
• W2912685222 creator A5002724338 @default.
• W2912685222 creator A5015067084 @default.
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• W2912685222 creator A5057269336 @default.
• W2912685222 creator A5059528441 @default.
• W2912685222 date "2019-01-31" @default.
• W2912685222 modified "2023-10-17" @default.
• W2912685222 title "pAKT pathway activation is associated with PIK3CA mutations and good prognosis in luminal breast cancer in contrast to p-mTOR pathway activation" @default.
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• W2912685222 cites W1984621921 @default.
• W2912685222 cites W1997695524 @default.
• W2912685222 cites W1999463736 @default.
• W2912685222 cites W2003659422 @default.
• W2912685222 cites W2005895632 @default.
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• W2912685222 cites W2036704696 @default.
• W2912685222 cites W2041811289 @default.
• W2912685222 cites W2044702943 @default.
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• W2912685222 cites W2062620611 @default.
• W2912685222 cites W2063281610 @default.
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• W2912685222 doi "https://doi.org/10.1038/s41523-019-0102-1" @default.
• W2912685222 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6355773" @default.
• W2912685222 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30729154" @default.
• W2912685222 hasPublicationYear "2019" @default.
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