Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912691761> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2912691761 endingPage "24" @default.
- W2912691761 startingPage "24" @default.
- W2912691761 abstract "Epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) mutational analysis in adenocarcinoma lung are growing in importance as these tests are essential in guiding the use of targeted therapy. However, the prevalence of these mutations in various populations in India has not been studied. Furthermore, the correlation of histologic pattern with the mutation is not clear.A total of 64 biopsy-proven lung adenocarcinomas were selected. In 51 of these, EGFR mutational analysis was performed using Qiagen EGFR pyrosequencing kit and in 56 cases of these ALK1 immunohistochemistry (IHC) was done using ALK (D5F3) antibody and the Ventana Benchmark® XT automated IHC slide staining system for the detection of overexpression. The adenocarcinomas were classified into well, moderate, and poorly differentiated, and the histological pattern was recorded according to the WHO 2014 classification.EGFR mutation was positive in 23 cases (45.10%) and positive ALK1 expression by IHC in 12 cases (21.43%). Both mutations were positive in two cases. Both mutations were seen in well-differentiated and moderately differentiated adenocarcinoma, and the expression was highest in tumors with a predominant acinar pattern.The incidence of both EGFR and ALK1 mutations is higher in the population studied and seem to correlate with a well differentiated, acinar pattern on morphology." @default.
- W2912691761 created "2019-02-21" @default.
- W2912691761 creator A5013848393 @default.
- W2912691761 creator A5022030299 @default.
- W2912691761 creator A5079191628 @default.
- W2912691761 date "2019-01-01" @default.
- W2912691761 modified "2023-10-16" @default.
- W2912691761 title "Epidermal growth factor receptor and anaplastic lymphoma kinase mutation in adenocarcinoma lung: Their incidence and correlation with histologic patterns" @default.
- W2912691761 doi "https://doi.org/10.4103/ijpm.ijpm_516_16" @default.
- W2912691761 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30706855" @default.
- W2912691761 hasPublicationYear "2019" @default.
- W2912691761 type Work @default.
- W2912691761 sameAs 2912691761 @default.
- W2912691761 citedByCount "3" @default.
- W2912691761 countsByYear W29126917612019 @default.
- W2912691761 countsByYear W29126917612021 @default.
- W2912691761 countsByYear W29126917612022 @default.
- W2912691761 crossrefType "journal-article" @default.
- W2912691761 hasAuthorship W2912691761A5013848393 @default.
- W2912691761 hasAuthorship W2912691761A5022030299 @default.
- W2912691761 hasAuthorship W2912691761A5079191628 @default.
- W2912691761 hasBestOaLocation W29126917611 @default.
- W2912691761 hasConcept C117643217 @default.
- W2912691761 hasConcept C121608353 @default.
- W2912691761 hasConcept C126322002 @default.
- W2912691761 hasConcept C142724271 @default.
- W2912691761 hasConcept C204232928 @default.
- W2912691761 hasConcept C2775934546 @default.
- W2912691761 hasConcept C2776232967 @default.
- W2912691761 hasConcept C2776256026 @default.
- W2912691761 hasConcept C2777714996 @default.
- W2912691761 hasConcept C2779438470 @default.
- W2912691761 hasConcept C2781182431 @default.
- W2912691761 hasConcept C2908647359 @default.
- W2912691761 hasConcept C502942594 @default.
- W2912691761 hasConcept C71924100 @default.
- W2912691761 hasConcept C86803240 @default.
- W2912691761 hasConcept C99454951 @default.
- W2912691761 hasConceptScore W2912691761C117643217 @default.
- W2912691761 hasConceptScore W2912691761C121608353 @default.
- W2912691761 hasConceptScore W2912691761C126322002 @default.
- W2912691761 hasConceptScore W2912691761C142724271 @default.
- W2912691761 hasConceptScore W2912691761C204232928 @default.
- W2912691761 hasConceptScore W2912691761C2775934546 @default.
- W2912691761 hasConceptScore W2912691761C2776232967 @default.
- W2912691761 hasConceptScore W2912691761C2776256026 @default.
- W2912691761 hasConceptScore W2912691761C2777714996 @default.
- W2912691761 hasConceptScore W2912691761C2779438470 @default.
- W2912691761 hasConceptScore W2912691761C2781182431 @default.
- W2912691761 hasConceptScore W2912691761C2908647359 @default.
- W2912691761 hasConceptScore W2912691761C502942594 @default.
- W2912691761 hasConceptScore W2912691761C71924100 @default.
- W2912691761 hasConceptScore W2912691761C86803240 @default.
- W2912691761 hasConceptScore W2912691761C99454951 @default.
- W2912691761 hasIssue "1" @default.
- W2912691761 hasLocation W29126917611 @default.
- W2912691761 hasLocation W29126917612 @default.
- W2912691761 hasOpenAccess W2912691761 @default.
- W2912691761 hasPrimaryLocation W29126917611 @default.
- W2912691761 hasRelatedWork W1546009185 @default.
- W2912691761 hasRelatedWork W1591408781 @default.
- W2912691761 hasRelatedWork W1600335608 @default.
- W2912691761 hasRelatedWork W1889913689 @default.
- W2912691761 hasRelatedWork W2374494252 @default.
- W2912691761 hasRelatedWork W2980579765 @default.
- W2912691761 hasRelatedWork W2998686349 @default.
- W2912691761 hasRelatedWork W3091209066 @default.
- W2912691761 hasRelatedWork W3152416472 @default.
- W2912691761 hasRelatedWork W3152767218 @default.
- W2912691761 hasVolume "62" @default.
- W2912691761 isParatext "false" @default.
- W2912691761 isRetracted "false" @default.
- W2912691761 magId "2912691761" @default.
- W2912691761 workType "article" @default.