Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912693463> ?p ?o ?g. }
Showing items 1 to 50 of
50
with 100 items per page.
- W2912693463 abstract "703 Background: In metastatic colorectal cancer (CRC), pharmacogenomics (PGx) testing presents a unique opportunity to improve outcomes since the genes DPYD & UGT1A1 encoding the enzymes metabolizing the chemotherapy drugs, 5-fluorouracil and irinotecan, are already well known. In the TRIBE clinical trial, proportion of patients with serious adverse events (SAEs) was higher in those with DPYD/UGT1A1 aberrations and were dose dependent. Critical barrier has been integration into clinical practice. We aimed to report on the feasibility and results of incorporating PGx testing into clinical practice. Methods: As a quality improvement initiative, we integrated the use of OneOme RightMed comprehensive test through funding from our center of individualized medicine, which reports on 28 genes and over 350 medications of interest. Pharmacists provided dosage recommendations based on test results real-time. Results: 126 patients have had the PGx testing since November 2017. Results have been available within 3-5 days. The table outlines the analyzed results thus far of variants in UGT1A1 and the DPYD-genes alongside the CYP450 genes. Of these, 59% had a DPYD/UGT1A1 aberration and 100% had at least one actionable aberration related to supportive care medications from all possible medications listed on their PGx report. Conclusions: Preemptive comprehensive PGx testing can be integrated into clinical practice in real-time for cancer patients. This sets the stage for a prospective randomized clinical trial to demonstrate the amount of benefit this can result in these patients. [Table: see text]" @default.
- W2912693463 created "2019-02-21" @default.
- W2912693463 creator A5014552801 @default.
- W2912693463 creator A5025919298 @default.
- W2912693463 creator A5031074845 @default.
- W2912693463 creator A5077416215 @default.
- W2912693463 creator A5081003447 @default.
- W2912693463 creator A5083469851 @default.
- W2912693463 creator A5087451903 @default.
- W2912693463 date "2019-02-01" @default.
- W2912693463 modified "2023-09-23" @default.
- W2912693463 title "Pharmacogenomics-guided chemotherapy and supportive care for patients with metastatic colorectal cancer." @default.
- W2912693463 doi "https://doi.org/10.1200/jco.2019.37.4_suppl.703" @default.
- W2912693463 hasPublicationYear "2019" @default.
- W2912693463 type Work @default.
- W2912693463 sameAs 2912693463 @default.
- W2912693463 citedByCount "0" @default.
- W2912693463 crossrefType "journal-article" @default.
- W2912693463 hasAuthorship W2912693463A5014552801 @default.
- W2912693463 hasAuthorship W2912693463A5025919298 @default.
- W2912693463 hasAuthorship W2912693463A5031074845 @default.
- W2912693463 hasAuthorship W2912693463A5077416215 @default.
- W2912693463 hasAuthorship W2912693463A5081003447 @default.
- W2912693463 hasAuthorship W2912693463A5083469851 @default.
- W2912693463 hasAuthorship W2912693463A5087451903 @default.
- W2912693463 hasConcept C121608353 @default.
- W2912693463 hasConcept C126322002 @default.
- W2912693463 hasConcept C143998085 @default.
- W2912693463 hasConcept C170734499 @default.
- W2912693463 hasConcept C177713679 @default.
- W2912693463 hasConcept C2776694085 @default.
- W2912693463 hasConcept C526805850 @default.
- W2912693463 hasConcept C71924100 @default.
- W2912693463 hasConcept C98274493 @default.
- W2912693463 hasConceptScore W2912693463C121608353 @default.
- W2912693463 hasConceptScore W2912693463C126322002 @default.
- W2912693463 hasConceptScore W2912693463C143998085 @default.
- W2912693463 hasConceptScore W2912693463C170734499 @default.
- W2912693463 hasConceptScore W2912693463C177713679 @default.
- W2912693463 hasConceptScore W2912693463C2776694085 @default.
- W2912693463 hasConceptScore W2912693463C526805850 @default.
- W2912693463 hasConceptScore W2912693463C71924100 @default.
- W2912693463 hasConceptScore W2912693463C98274493 @default.
- W2912693463 hasLocation W29126934631 @default.
- W2912693463 hasOpenAccess W2912693463 @default.
- W2912693463 hasPrimaryLocation W29126934631 @default.
- W2912693463 isParatext "false" @default.
- W2912693463 isRetracted "false" @default.
- W2912693463 magId "2912693463" @default.
- W2912693463 workType "article" @default.