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• W2912694162 abstract "In the present study, we introduce a new concept termed frequency hopping dielectrophoresis (DEP) to enable a tunable microfluidic platform for microscale particle sorting. Frequency hopping DEP is used to provide a modulating force field leveraging the frequency-dependent response of polarizable particles to a non-uniform electric field. The proposed DEP platform operates by adjusting the signal parameters where a sinusoidal/square wave hops between two frequencies with a constant voltage amplitude. The two frequencies are selected such that one provides maximal DEP force (trapping frequency) and the other induces the minimal DEP force (release frequency). Analogously, the proposed DEP signaling scheme acts like the conventional microfluidic filters in which the filter size is tuned by modifying the DEP magnitude through the frequency-dependent behavior of particles. To this end, the proof-of-concept experiments were performed for the sorting of polystyrene particles of 3, 5 and 10 μm in diameter in a mixture with sorting efficiencies as high as 98.7%. The protocol was then applied for the enrichment of MCF7 cells spiked in diluted blood samples to achieve capture efficiencies as high as 82.2%." @default.
• W2912694162 created "2019-02-21" @default.
• W2912694162 creator A5044659039 @default.
• W2912694162 creator A5050052771 @default.
• W2912694162 date "2019-05-01" @default.
• W2912694162 modified "2023-10-01" @default.
• W2912694162 title "Frequency hopping dielectrophoresis as a new approach for microscale particle and cell enrichment" @default.
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• W2912694162 doi "https://doi.org/10.1016/j.snb.2019.01.157" @default.
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