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- W2912697256 abstract "Local and regional anesthetic techniques are gaining widespread acceptance in the management of pain in small and large animals. They penetrate peripheral nerves and induce reversible blockade of impulse conduction in myelinated and unmyelinated nerve fibers by inhibiting voltage-gated sodium channels. The local anesthetics block the conduction of nerve impulses by inhibiting voltage-gated sodium channels in neuronal membranes. Administration of an incorrect dose and inadvertent intravenous administration of the local anesthetics are probably the most common causes of systemic toxicity. Local anesthetics can also be given systemically to manage perioperative pain and ileus. They are often used in combination with other classes of analgesic drugs as part of a multi-modal pain management strategy. The local anesthetics have the unique ability to produce complete blockade of peripheral nociceptive input, preventing the development of pathological pain as well as the stress response." @default.
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- W2912697256 date "2013-12-20" @default.
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- W2912697256 title "Local Anesthetics" @default.
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