FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912698023> ?p ?o ?g. }

• W2912698023 endingPage "1231" @default.
• W2912698023 startingPage "1220" @default.
• W2912698023 abstract "BACKGROUND:PGC-1α can be activated by deacetylation reactions catalyzed by SIRT1. Resveratrol is currently known as a potent activator of SIRT1. However, it is unknown whether the renal-protective effect of resveratrol is further related to activation of the podocyte SIRT1/PGC-1α pathway. MATERIAL AND METHODS:High glucose was used to stimulate mouse podocytes. Resveratrol and PGC-1α siRNA transfection were used to perform co-intervention treatments. The protein and mRNA expression levels of SIRT1, PGC-1α, NRF1, and TFAM were detect by immunofluorescence, Western blot analysis, and qRT-PCR in the podocytes, respectively. DCHF-DA and MitoSOX™ staining were used to monitor the total ROS and mitochondrial ROS levels, respectively. The specific activities of complexes I and III were measured using Complex I and III Assay Kits. Mitochondrial membrane potential and cell apoptosis were measured using JC-1 staining and Annexin V-FITC/PI double-staining, respectively. RESULTS:We found that high-glucose stimulation results in time-dependent decreases in the expression of SIRT1, PGC-1α, and its downstream genes NRF1 and mitochondrial transcription factor A (TFAM) for mouse podocytes, and increases ROS levels in cells and mitochondria. Moreover, the expression of nephrin was downregulated and the cell apoptotic rate was increased. Resveratrol treatment can improve abnormalities caused by high-glucose stimulation. In addition, it can also reduce the release of mitochondrial cytochrome C and DIABLO proteins to the cytoplasm and increase respiratory chain complex I and III activity and mitochondrial membrane potential. CONCLUSIONS:Resveratrol can reduce the oxidative damage and apoptosis of podocytes induced by high-glucose stimulation via SIRT1/PGC-1α-mediated mitochondrial protection." @default.
• W2912698023 created "2019-02-21" @default.
• W2912698023 creator A5033907951 @default.
• W2912698023 creator A5035701638 @default.
• W2912698023 creator A5060002817 @default.
• W2912698023 creator A5064917716 @default.
• W2912698023 creator A5075482179 @default.
• W2912698023 creator A5084119252 @default.
• W2912698023 date "2019-02-15" @default.
• W2912698023 modified "2023-10-17" @default.
• W2912698023 title "Resveratrol Reduces Oxidative Stress and Apoptosis in Podocytes via Sir2-Related Enzymes, Sirtuins1 (SIRT1)/Peroxisome Proliferator-Activated Receptor γ Co-Activator 1α (PGC-1α) Axis" @default.
• W2912698023 cites W1599948477 @default.
• W2912698023 cites W1971679612 @default.
• W2912698023 cites W1990886132 @default.
• W2912698023 cites W2010312807 @default.
• W2912698023 cites W2020040871 @default.
• W2912698023 cites W2025991566 @default.
• W2912698023 cites W2035593978 @default.
• W2912698023 cites W2041085893 @default.
• W2912698023 cites W2042685228 @default.
• W2912698023 cites W2044437167 @default.
• W2912698023 cites W2049481764 @default.
• W2912698023 cites W2050425575 @default.
• W2912698023 cites W2092819514 @default.
• W2912698023 cites W2099082614 @default.
• W2912698023 cites W2099760082 @default.
• W2912698023 cites W2102235083 @default.
• W2912698023 cites W2105404724 @default.
• W2912698023 cites W2124595934 @default.
• W2912698023 cites W2129622471 @default.
• W2912698023 cites W2138881396 @default.
• W2912698023 cites W2140925956 @default.
• W2912698023 cites W2152101492 @default.
• W2912698023 cites W2156090275 @default.
• W2912698023 cites W2159383423 @default.
• W2912698023 cites W2164934883 @default.
• W2912698023 cites W2169976250 @default.
• W2912698023 cites W2338184168 @default.
• W2912698023 cites W2479269302 @default.
• W2912698023 cites W2561113108 @default.
• W2912698023 cites W2598444458 @default.
• W2912698023 cites W2743056880 @default.
• W2912698023 cites W2795360915 @default.
• W2912698023 cites W2796041684 @default.
• W2912698023 cites W2911257567 @default.
• W2912698023 doi "https://doi.org/10.12659/msm.911714" @default.
• W2912698023 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6383436" @default.
• W2912698023 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30765684" @default.
• W2912698023 hasPublicationYear "2019" @default.
• W2912698023 type Work @default.
• W2912698023 sameAs 2912698023 @default.
• W2912698023 citedByCount "45" @default.
• W2912698023 countsByYear W29126980232019 @default.
• W2912698023 countsByYear W29126980232020 @default.
• W2912698023 countsByYear W29126980232021 @default.
• W2912698023 countsByYear W29126980232022 @default.
• W2912698023 countsByYear W29126980232023 @default.
• W2912698023 crossrefType "journal-article" @default.
• W2912698023 hasAuthorship W2912698023A5033907951 @default.
• W2912698023 hasAuthorship W2912698023A5035701638 @default.
• W2912698023 hasAuthorship W2912698023A5060002817 @default.
• W2912698023 hasAuthorship W2912698023A5064917716 @default.
• W2912698023 hasAuthorship W2912698023A5075482179 @default.
• W2912698023 hasAuthorship W2912698023A5084119252 @default.
• W2912698023 hasBestOaLocation W29126980232 @default.
• W2912698023 hasConcept C104317684 @default.
• W2912698023 hasConcept C127561419 @default.
• W2912698023 hasConcept C153911025 @default.
• W2912698023 hasConcept C169415338 @default.
• W2912698023 hasConcept C185592680 @default.
• W2912698023 hasConcept C190283241 @default.
• W2912698023 hasConcept C2776151105 @default.
• W2912698023 hasConcept C2776536020 @default.
• W2912698023 hasConcept C2776816829 @default.
• W2912698023 hasConcept C2777229759 @default.
• W2912698023 hasConcept C2778175917 @default.
• W2912698023 hasConcept C28859421 @default.
• W2912698023 hasConcept C55493867 @default.
• W2912698023 hasConcept C74438686 @default.
• W2912698023 hasConcept C86803240 @default.
• W2912698023 hasConcept C88634738 @default.
• W2912698023 hasConcept C95444343 @default.
• W2912698023 hasConceptScore W2912698023C104317684 @default.
• W2912698023 hasConceptScore W2912698023C127561419 @default.
• W2912698023 hasConceptScore W2912698023C153911025 @default.
• W2912698023 hasConceptScore W2912698023C169415338 @default.
• W2912698023 hasConceptScore W2912698023C185592680 @default.
• W2912698023 hasConceptScore W2912698023C190283241 @default.
• W2912698023 hasConceptScore W2912698023C2776151105 @default.
• W2912698023 hasConceptScore W2912698023C2776536020 @default.
• W2912698023 hasConceptScore W2912698023C2776816829 @default.
• W2912698023 hasConceptScore W2912698023C2777229759 @default.
• W2912698023 hasConceptScore W2912698023C2778175917 @default.
• W2912698023 hasConceptScore W2912698023C28859421 @default.
• W2912698023 hasConceptScore W2912698023C55493867 @default.
• W2912698023 hasConceptScore W2912698023C74438686 @default.
• W2912698023 hasConceptScore W2912698023C86803240 @default.
• W2912698023 hasConceptScore W2912698023C88634738 @default.

• next